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血清S100β蛋白及IL-10含量预测急性脑出血患者迟发性脑水肿的临床意义 被引量:3

Clinical significance of serum levels of S100β protein and IL-10 in predicting delayed cerebral edema in patients with acute cerebral hemorrhage
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摘要 目的探讨血清S100β蛋白及IL-10含量预测急性脑出血患者迟发性脑水肿的临床意义。方法选择我院2015年7月到2016年2月收治的并发迟发性脑水肿的急性脑出血患者36例作为观察组,选择同期非迟发性脑水肿的急性脑出血患者64例作为对照组。对两组患者入院后第1、7、14、21、28天进行头颅MRI检查,观察脑出血量及血肿周围水肿量;测定比较两组患者在第1、7、14、21、28天的血清S100β蛋白、IL-10含量。结果观察组第1、7、14、21、28天的脑出血量、脑水肿量、血清S100β蛋白、IL-10含量均明显高于对照组(P<0.05)。结论急性脑出血患者的血清S100β蛋白及IL-10含量可以有效地预测迟发性脑水肿,与脑颅MRI相结合,对预防急性脑出血患者并发迟发性脑水肿具有很高的临床意义。 Objective To study the clinical significance of serum S100β protein and IL-10 in predicting the delayed cerebral edema of patients with acute cerebral hemorrhage.Methods A total of36 patients with acute cerebral hemorrhage complicated with delayed cerebral hemorrhage admitted to our hospital From July 2015 to February 2016 were chosen as observation group,and 64 patients with acute cerebral hemorrhage not complicated with delayed cerebral hemorrhage were selected as the control group.Head MRI examination was performed in two groups of patients at first day,seventh day,fourteenth day,twenty-first day and twenty-eighth day.The amount of cerebral hemorrhage and edema around hematoma were observed.Serum levels of S100βand IL-10 were measured in two groups of patients at first day,seventh day,fourteenth day,twentyfirst day and twenty-eighth day.Results The amount of cerebral hemorrhage,cerebral edema,serum S100βand IL-10 in the observation group at first day,seventh day,fourteenth day,twenty-first day and twenty-eighth day were significantly higher than those in the control group(P<0.05).Conclusion The serum levels of S100βand IL-10 in patients with acute cerebral hemorrhage can effectively predict the delayed cerebral edema.Combined with cranial MRI,it has a high clinical significance in preventing acute cerebral hemorrhage complicated with delayed cerebral edema.
作者 张伟超 胡朝晖 郑永汉 ZHANG Wei-chao;HU Chao-hui;ZHENG Yong-han(Sanshui District Peoplers Hospital of Foshan,Foshan,Guangdong 528100,China)
出处 《青岛医药卫生》 2016年第3期175-177,共3页 Qingdao Medical Journal
关键词 迟发性脑水肿 急性脑出血 血清S100|3蛋白 IL-10 Delayed cerebral edema Acute cerebral hemorrhage Serum S100β protein IL-10
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