两种超促排卵方案治疗卵巢低反应患者效果比较

Comparison of two ovarian stimulation regimens in poor ovarian responders

目的探讨体外受精-胚胎移植(IVF-ET)过程中短效长方案与低剂量长效长方案在卵巢低反应患者中的应用效果。方法选择2013年1月至2014年3月在深圳武警医院生殖中心接受IVF-ET(长方案)治疗的卵巢低反应代偿期患者291例,根据降调节方案分成两组,短效长方案组(A组)139例和低剂量长效长方案组(B组)152例,比较两组的一般情况、促排卵情况及治疗结局。结果 A组的促性腺激素(Gn)用量及Gn天数明显少于B组,临床妊娠率高于B组,而周期取消率、早期流产率低于B组,差异有统计学意义(P<0.05)。结论对卵巢低反应代偿期患者,短效长方案可获得较低剂量长效长方案更满意的临床效果。

Objective To analyze the effect of short acting rectangular case and low dose long rectangular case in vitro fertilization and embryo transfer(IVF-ET)in poor ovarian responders.Methods From January 2013 to March 2014,291 poor ovarian responders who accepted IVF-ET in Shenzhen Armed Police Hospital were divided into two groups,139 patients of short acting rectangular case group(A group)and 152 patients of low dose long rectangular case group(B group).Two groups were compared in general,ovulation and treatment outcome.Results Gn amounts and Gn days of A group were significantly less than group B,clinical pregnancy rate were higher than group B,while the cycle cancellation rate,early abortion rate were lower than group B.Conclusion For poor ovarian responders in compensatory stage,the short acting rectangular case may have a more satisfactory clinical effect.