利拉鲁肽治疗106例老年2型糖尿病的疗效观察

Effect observation of Liraglutide treatment in type 2 diabetes patients

目的:观察利拉鲁肽治疗老年2型糖尿病的临床疗效。方法:选取106例2型糖尿病老年患者,给予利拉鲁肽0.6 mg皮下注射,1次/d,1周后增加至1.2 mg,治疗前和治疗16周后,检测患者空腹血糖(FPG)、2 h餐后血糖(2hPG)、糖化血红蛋白(HbA1c)、体重指数(BMI)和胰岛素功能,治疗期间观察患者低血糖反应情况及肝功能、肾功能、淀粉酶、血常规、血脂水平。结果:16周治疗后患者FPG、2hPG、HbA1c、BMI和胰岛素抵抗指数均明显下降,胰岛β细胞功能指数明显升高(P均<0.05),低血糖等不良反应轻微。结论:利拉鲁肽治疗2型糖尿病能显著改善患者血糖谱,改善胰岛细胞功能,有良好的效果和安全性,是老年2型糖尿病患者有效而安全的治疗方案。

Objective To explore the clinical effects of Liraglutide on the elder patients with type 2 diabetes. Method 106 casesof patients with type 2 diabetes were selected. The elder patients were treated with Liraglutide alone, the levels of fasting plasmaglucose (FPG) ,2 -hour plasma glucose (2 h PG) , haemoglobin Ale (HbAlc) ,Body mass index (BMI) and homeostasis modelassessment of insulin resistance were detected before treatment and 16 weeks after treatment. Hypoglycemia, liver function, renalfunction, blood routine, blood lipid level were observed during the treatment. Results After 16 weeks treatment, the levels of fastingplasma glucose (FPG) ,2 -hour plasma glucose (2 h PG) ,haemoglobin Ale (HbAlc) ,Body mass index (BMI) and homeostasismodel assessment of insulin resistance ( HOMA - IR) were significantly lower, whereas homeostasis model assessment of p - cellfunction (HOMA - p) was significantly higher (P <0. 05). Hypogly cemia and other adverse reactions were mild. Conclusion Thetherapeutic regimen of Liraglutide significantly improves function of p cells,reduces levels of glucose and appears to be a beneficialtreatment for type 2 diabetes patients.