摘要
目的:调查我院初诊2型糖尿病的老年患者常用的三组口服降糖药物治疗方案,进行3个治疗方案的成本-效果分析,并了解低血糖发生比例,为老年患者选择降糖治疗方案提供参考。方法:采用回顾性调查,将我院初诊2型糖尿病的老年患者,均在口服二甲双胍的基础上,A组加用格列美脲,B组加用瑞格列奈,C组加用吡格列酮,采集监测的血糖值和糖化血红蛋白作为效果测量指标,进行成本-效果分析,并统计低血糖发生次数。结果:三组间患者的基本情况比较,差异无统计学意义(P>0.05)。ABC组治疗方案的药物成本均数为675.15元,875.95元,650.15元,3组治疗方案效价比A组大于B、C组,B组和C组之间无统计学差异,A组发生低血糖比例明显大于B、C组。结论:对于2型糖尿病患者的初始治疗,选用格列美脲联合二甲双胍的治疗方案效价比高,但低血糖发生率高。高龄、智能和认知障碍、自理能力差、肝肾功能减退、预计远期寿命较短的患者可选择使用瑞格列奈的治疗方案。
Objective To investigate commonly used three oral hypoglycemic drug treatment programs in elderly patients ofnewly diagnosed type 2 diabetes in our hospital,analyse their cost - effectiveness,and learn hypoglycemia rate,to provide a referenceof antidiabetic treatment options for elderly patients. Method Retrospective survey was performed, elderly patients of newly diagnosedtype 2 diabetes in our hospital were treated with Glimepiride ( Group A) , Repaglinide ( Group B) and Pioglitazone ( Group C ),respectively, besides oral metformin. Blood glucose levels and glycated hemoglobin were measurement indicators, cost - effectivenessof three treatment programs were analysed,the number of statistical hypoglycemia was calculated. Results The basic situation wasno significant difference among the three groups of patients(P >0. 05). Average drug costs of Group A,B and C were ¥675. 15,875. 95 and 650. 15 Respectively,program A had a higher cost - effectiveness than program B and C,there was no significant differencebetween program B and C. Hypoglycemia rate in group A was significantly greater than group B, C. Conclusion For the initialtreatment of type 2 diabetes, Glimepiride in combination with metformin has a higher cost - effectiveness and hypoglycemiarate. Patients with age, cognitive disorders, poor self - care, liver and kidney dysfunction, expected long - term short - life may useRepaglinide treatment.
作者
莫焕娇
杨滔
陈国强
李秋玲
MO Huan - jiao;YANG Tao;CHEN Guo -qiang;LI Qiu(Department of pharmacy ,Qiaotou hospital of Dongguan City,Guangdong Province,Dongguan 52352Q,China)
出处
《吉林医学》
CAS
2016年第7期1623-1625,共3页
Jilin Medical Journal
关键词
初诊2型糖尿病
格列美脲
瑞格列奈
p比格列酮
成本-效果分析
低血糖
Newly diagnosed type 2 diabetes
Glimepiride
Repaglinide
Pioglitazone
Cost - effectiveness analysis
Hypoglycemia