他汀应用于心房颤动防治的研究进展

Advances of research on statin's application in atrial fibrillation control

心房颤动(atrial fibrillation,AF)是最常见的公共健康问题,研究显示炎症和心肌细胞氧化应激参与心房的结构重构和电重构,进而成为AF的潜在发病机制。他汀类药物是3-羟甲基-3-戊二单酰辅酶A(HMG-Co A)还原酶抑制剂,除降脂外,兼有抗炎、抗氧化应激作用。他汀通过抗炎、抗氧化应激改善心房重构来降低AF的发病率。但是,在临床实践中,他汀的抗心律失常属性并未得到完全阐明,有关他汀在AF一级及二级预防中的结论备受争议。

Atrial fibrillation ( AF) is the most common public health problem. It has been revealed by research that inflammation and oxidative stress of cardiac muscle cell involve in the structural and electrical remodeling of atrium, which becomes the underlying pathogenesis of AF furtherly.Statins is a kind of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor. Besides the efficacy of lipid-lowering, statin drugs are also anti-inflammatory and anti-oxidative-stress, which improves the remodeling of atrium and thus reduces the incidence of AF. However, the anti-arrhythmic property of statin has not been completely illuminated in clinical practice. Conclusions about its application in the primary or secondary prevention of AF remain controversial