两种干预模式对替诺福韦-拉米夫定、依非韦伦方案抗病毒治疗疗效影响的评价

Two Intervention Modes of Tenofovir and Lamivudine, According to the Non-the Antiviral Treatment Curative Effect Influence of Program Evaluation

目的比较常规干预模式和加强模式对艾滋病病毒(HIV)/艾滋病(AIDS)病人(简称HIV/AIDS病人)使用替诺福韦-拉米夫定、依非韦伦方案抗病毒治疗疗效影响,探讨基于首选方案下资源有限地区适宜的干预模式。方法选取2013年1月—2014年6月抗反转录病毒治疗(ART)1年的185例HIV/AIDS病人随机分成常规干预模式组86例和加强干预模式组99例,比较两组患者治疗后CD4+T淋巴细胞(简称CD4细胞)及病毒载量抑制率的差异情况。结果在不同的基线CD4细胞计数水平情况下加强组与常规组在治疗后不同时期的CD4细胞计数相互比较差异无统计学意义(P>0.05)。两组患者在治疗后6个月、12个月的病毒载量抑制率相互比较差异无统计学意义(P>0.05)。结论初治使用TDF+3TC+EFV首选方案的HIV/AIDS病人比较常规的干预模式和加强干预模式对抗病毒的疗效影响上无明显差异。采用常规模式达到理想的抗病毒治疗疗效,适宜艾滋病治疗医护资源有限地区的推广运用。

Objective Compared with conventional mode of intervention models and strengthen the AIDS virus (HIV)/AIDS(AIDS) patients (referred to HIV/AIDS patients) with tenofovir-lamivudine, efavirdine program effect of antiviral therapy, discussion on resource-limited settings based on preferred options appropriate intervention models. Methods Selection of January 2013 to 2014 June antiretroviral therapy (ART) 1 years of 185 cases of HIV/AIDS patients were randomly divided into routine intervention model group 86 cases and strengthen the intervention model group of 99 cases, compare the two groups after treatment in patients with CD4 T cells (CD4 cells) and viral load suppression rate differences. Results At different baseline CD4 cell count levels in the case of enhanced group and the conventional group at different times after treatment CD4 cell count was not statistically significant difference(P>0.05). Two groups of patients after treatment 6 months, 12 months of viral load suppression rate compared with each other, there was no significant difference (P>0.05). Conclusion Compared with the conventional intervention mode and strengthening the intervention mode, the effect of the treatment on the efficacy of the virus was not significantly different between the patients with primary treatment and the use of TDF+3TC+EFV. The use of conventional mode to achieve the desired effect of antiviral therapy, suitable for the promotion of AIDS treatment of health care resources in the limited area.