氯米帕明与艾司西酞普兰对强迫症患者执行能力的影响

Effects of Escitalopram and Clomipramine on executive aiblity in patients with obsessive-compulsive disorder

目的:探索氯米帕明与艾司西酞普兰对强迫症患者执行能力的影响。方法:将90例强迫症患者随机分为对照组和观察组,每组各45例。对照组患者给予氯米帕明进行治疗;观察组患者给予艾司西酞普兰进行治疗。两组患者的疗程均为2个月。在治疗前和治疗后1个月、2个月时,采用耶鲁布朗强迫症表(Y-BOCS)对两组患者的疗效及病情进行评估,采用彩色文字阅读测验(Stroop-C、Stroop-CW)和连线测验(TMT)评估两组患者的执行能力情况。结果:治疗2个月后,观察组患者的Stroop-C为(52.8±7.9)s、Stroop-CW为(127.6±16.8)s、TMT-B为(46.1±8.2)s;对照组患者的Stroop-C为(58.8±7.6)s、Stroop-CW为(138.1±16.3)s、TMT-B为(52.3±7.7)s,两组患者比较,差异有统计学意义(P<0.05)。治疗1个月和2个月后,观察组患者的Y-BOCS评分及强迫行为因子、强迫观念也明显低于对照组(P<0.05)。结论:艾司西酞普兰用于治疗强迫症患者,可明显改善其执行能力,临床效果显著且不良反应小。

Objective: To explore effects of Clomipramine and Escitalopram on executive ability in ( Obsessive-compulsive disorder) OCD patients. Methods:90 OCD patients were randomly divided into control group (45 patients, receiving Clomipramine treatment for 2 months) and observation group (45 cases, accepting silver Escitalopram treatment for 2 months). Before and 1 and 2 months after the treatment, the efficacy and disease conditions were evaluated by Yale Brown obsessive-compulsive disorder table ( Y-BOCS), and the executive abilities were assessed by colored text reading test (Stroop-C, Stroop-CW) and the trail making test ( TMT) . Results:2 months after the treatment, the scores of Stroop-C, Stroop-CW, and TMT-B of observation group vs. control group were (52. 8±7. 9) vs. (58. 8±7. 6), (127. 6±16. 8) vs. (138. 1±16. 3), and (46. 1±8. 2) vs. (52. 3±7. 7), separately, and the differences were statistically significant (P<0. 05). 1 and 2 months after the treatment, the Y-BOCS score and the factor scores of compulsive behavior and obsessive ideas of observation group were obviously lower than those of control group (P<0. 05). Conclusions:For the treatment of the patients with obsessive-compulsive disorder, Escitalopram can significantly improve their execu-tive with significant clinical effects and less adverse reactions.