miR-26a调控Sox6和Bhlhe22表达对胰岛素分泌的影响

Effects of Sox6 and Bhlhe22 expression controlled by mi R-26a on insulin secretion

目的:胰腺发育过程涉及多种转录因子和信号通路,在糖尿病的发病中起重要作用。mi RNA可以调控胰岛β细胞发育相关蛋白的表达。mi R-26a直接调节Sox6和Bhlhe22的表达以调控胰岛β细胞的发育,从而影响胰岛素分泌,参与糖尿病发病。

Pancreatic development involved multiple transcription factors and signaling pathways,which played an important rolein the pathogenesis of diabetes mellitus.MiRNA can regulate the expression of related protein for the development of pancreaticbeta cells.MiR-26a regulated the expression of Sox6 and Bhlhe22 directly in order to regulate the development of pancreatic betacells,so as to affect the insulin secretion and participate in the pathogenesis of diabetes.