右美托咪定滴鼻复合地佐辛对小儿七氟醚麻醉苏醒期躁动的影响

Effect of dexmedetomidine intranasal instillation combined with dezocine on restlessness during recovery period of sevoflurane anesthesia in children

目的：观察右美托咪定(Dex)术前滴鼻复合地佐辛对小儿七氟醚麻醉苏醒期的影响。方法：收治扁桃体切除术的3～10岁患儿60例，随机分为Dex组(D组)和对照组(C组)。术前30min，D组经鼻滴入Dex，C组经鼻滴入生理盐水，两组患儿手术结束前15min静脉注射地佐辛。观察和记录术后躁动评分、苏醒和拔管时间，不良反应发生率。结果：D组患儿在拔管后5min(T2)、10min(T3)、20min(T4)、30min(T5)、1h(T6)的躁动评分明显低于C组，差异有统计学意义(P＜0.05)。结论：Dex滴鼻复合地佐辛可有效预防小儿七氟醚麻醉苏醒期躁动，不延长苏醒和拔管时间，且不增加术后不良事件的发生。

Objective:To investigate the effect of dexmedetomidine intranasal instillation before surgery combined with dezocineon restlessness during recovery period of sevoflurane anesthesia in children.Methods:60 cases of 3～10 years old children withtonsillectomy were selected.They were randomly divided into the Dex group(the group D) and the control group(the C group).30minutes before operation,the D group received intranasal instillation of Dex,in the group C,the normal saline was received by nasaldrops.15 minutes before the end of surgery,intravenous administration of docetaxel was given to the two groups of patients.Weobserved and recorded the incidence of postoperative agitation score,recovery and extubation time,and the incidence of adversereactions.Results:The agitation scores of 5 min(T2),10 min(T3),20 min(T4),30 min(T5),1 h(T6)after extubation of the group D weresignificantly lower than those in the group C,and the differences were statistically significant(P<0.05).Conclusion:Dexmedetomidine intranasal instillation combined with dezocine can effectively prevent restlessness during recovery period ofsevoflurane anesthesia in children,which do not prolong the time of recovery and extubation,and do not increase the incidence ofpostoperative adverse events.