坦度螺酮治疗帕罗西汀引起男性性功能障碍的疗效观察

Observation on the curative effect of tandospirone for the male sexual dysfunction induced by paroxetine

目的:探讨坦度螺酮对帕罗西汀引起的性功能障碍(SD)的治疗作用。方法:筛选接受帕罗西汀单药治疗维持3个月以上,进行汉密尔顿焦虑量表(HAMA,17项)、汉密尔顿抑郁量表(HAMD,17项)评分,HAMA评分<7分和HAMD评分<7分的康复期患者,再进行亚利桑那性经验量表(ASEX)调查,筛选出SD(ASEX总分>19分)病例84例,再将此84例患者随机分为坦度螺酮30 mg治疗组和坦度螺酮60 mg治疗组。在治疗前、治疗4周、治疗8周后评定ASEX、国际勃起功能指数-5(IIEF-5)、改良的性生活质量调查表(m SLQQ-Qo L),对比治疗前后和组间的量表得分。结果:m SLQQ-Qo L总分的比较,2组患者在4周和8周时的m SLQQ-Qo L总分均有明显升高,差异有统计学意义(P<0.05);60 mg治疗组较30 mg治疗组m SLQQ-Qo L总分增加,差异有统计学意义(P<0.01)。勃起功能障碍痊愈率的比较,30 mg治疗组痊愈率为56%,60 mg治疗组痊愈率为62.5%,2组比较差异无统计学意义(x2=0.21,P=0.64)。结论:枸橼酸坦度螺酮对帕罗西汀引起的SD具有一定治疗作用,且存在一定的量效关系。

Objective: To investigate whether tandospirone can cure the male sexual dysfunction causedby paroxetine. Methods: Patients with the single treatment of paroxetine for more than 3 months were selected,evaluation of HAMA, HAMD-17 was adopted, HAMA score <7 points and HAMD score<7 points were choosedin the rehabilitation period patients, then Arizona Sexual Experience Scale (ASEX) was used. Eighty four patientswhose ASEX score>19 were randomly divided into two groups, with 30 mg/d and 60 mg/d of tandospironeof each group. ASEX, IIEF-5 and sex life quality questionnaire (mSLQQ-QoL) before treatment were evaluated,treatment for 4 weeks and 8 weeks. The scale before and after treatment and the scale between groups were contrasted.Results: Compared with the total score of mSLQQ-QoL, the two groups’ total average in 4 weeks and 8weeks all had been significantly increased (P<0.05), the two groups’ increased of total score of 30 mg/d and 60mg/d had been significantly increased (P<0.01); comparison on the cure rate of sexual dysfunction, the 30 mggroup was 56%, the 60 mg group was 62.5%, the two groups had no significant difference (x2=0.21, P=0.64).Conclusion: Tandospirone cure the sexual dysfunction caused by paroxetine has a certain therapeutic effect, andthere is a certain dose-effect relationship.