心力衰竭患者血清可溶性ST2及IL-6水平的临床意义

Clinical significance of serum soluble ST2 and IL-6 changes in patients with heart failure

目的探讨慢性心力衰竭患者血清可溶性ST2(s ST2)及IL-6水平变化及意义。方法选取2012年7月至2015年7月因心力衰竭住院的患者100例(心力衰竭组)和非心力衰竭住院患者60例(对照组)。按NYHA进行心功能分级。心脏超声检查测定左心室射血分数(LVEF)及左心室短轴收缩率(LVFS),测定血清NT-pro BNP水平,并应用酶联免疫吸附法检测入院时血清中s ST2、IL-6水平。结果心力衰竭组血清s ST2及IL-6水平明显高于对照组,血清s ST2及IL-6水平随心功能分级升高而升高,3组间比较差异均有统计学意义(均P<0.05)。心力衰竭患者血清s ST2及IL-6水平与NT-pro BNP、LVFS及LVEF呈负相关。结论心力衰竭患者s ST2及IL-6水平增高,并与心功能状态存在关联性。

Objective To investigate the changes and clinical significance of soluble ST2 protein (sST2) andinterleukin -6 in patients with chronic heart failure (HF). Methods 100 inpatients with HF (HF group) and 60 inpatientswithout HF (control group) were enrolled between July 2012 and July 2015.Heart function was graded based on NYHAheart function classification. The left ventricular ejection fraction (LVEF)and fractional shortening (LVFS) were measured bytwo-dimensional echocardiography. sST2 and IL-6 levels were measured by enzyme-linked immunosorbent assays atadmission.Serum NT-proBNP was measured. Results Serum sST2 and IL-6 in were significantly higher in HF groupthan control group. Serumlevels of sST2 and IL-6 increased significantly as the NYHA classification increased. SerumsST2and IL-6 level was negatively correlated with NT-ProBNP, LVFS and LVEF. Conclusion sST2 and IL-6 levels increase inpatients with HF and correlate with the severity of HF.