老年2型糖尿病周围神经病变患者治疗策略的研究

Study on the treatment strategy of elderly patients with type 2 diabetes mellitus diabetic peripheral neuropathy

目的:探讨药物联用对老年2型糖尿病周围神经病变的治疗效果。方法:收治老年2型糖尿病并发周围神经病变患者196例,随机分成4组,比较治疗效果。结果:1治疗后,4组患者的神经病变主觉症状评分均显著改善(P<0.05),且硫辛酸+前列地尔组与其他3组比较,差异有统计学意义(P<0.05)。2治疗后,依帕司他+硫辛酸+前列地尔组运动传导速度、感觉传导速度与其他3组比较,差异有统计学意义(P<0.05)。结论:3种药物联用治疗老年2型糖尿病周围神经病变的疗效优于两两药物联用。

Objective:To investigate the therapeutic effect of drug combination on peripheral neuropathy in elderly patients withtype 2 diabetes mellitus.Methods:196 elderly patients with type 2 diabetes mellitus complicated with peripheral neuropathy wereselected.They were randomly divided into four groups.We compared the treatment effects.Results:①After treatment,the scores ofmain symptoms of neuropathy in the four groups were significantly improved(P<0.05),and there were significant differencesbetween lipoic acid plus alprostadil group with the other three groups(P<0.05). ② After treatment,there were significantdifferences between epalrestat plus lipoic acid plus alprostadil group with other three groups in motor conduction velocity andsensory conduction velocity(P<0.05).Conclusion:Combination of the three drugs in the treatment of elderly patients with type 2diabetes mellitus was superior to the efficacy of two drugs combination.