肿瘤药物致肝损伤的原因及预防对策

Antitumor drugs cause liver damage causes and prevention countermeasures

在抗肿瘤的治疗中,药物手段作为较化疗、放疗更为安全的一种办法,收到患者的广泛接受。然而抗肿瘤药物往往毒副作用较大,不仅会对肿瘤细胞产生杀伤作用,更会对正常细胞有损害,特别是靶向性较差的药物。肝脏做为人体重要的药物代谢器官,在降低毒副作用、排出毒素起到至关重要的作用。但是,当它的运作超负荷时,肝脏亦会响起警报,甚至罢工。本文对抗肿瘤药物致肝损伤的危险因素进行分析,讨论预防对策。

In the treatment of anti-tumor , drug means as a chemotherapy , radiation therapy , a more secure way , received wide acceptance among patients . Antitumor drug side effects often larger , however , will not only effect on tumor cells to produce damage , more has the damage tonormal cells , especially the poor targeted drugs . Liver as drug metabolism of important organs , to reduce the side effects , eject toxin play a crucial role . However , when the operation of the overload , the liver also sounded the alarm , and even the strike . This article of antitumor drugs were analyzed, and the factors to cause the risk of liver damage to discuss preventive countermeasures .