重组人生长激素治疗溃疡性结肠炎临床对照研究

Clinical control study of recombinant human growth hormone in the treatment of ulcerative colitis

目的研究重组人生长激素(r-h GH)在溃疡性结肠炎(ulcerative colitis,UC)治疗中的作用。方法选取2011至2016年徐州医学院附属淮安医院溃疡性结肠炎患者55例,随机分组为研究组(30例)、对照组(25例),两组患者在年龄、职业、病程、肠镜下病变范围均有可比性,Mayo评分差异无统计学意义(t值=0.163,P=0.871)。两组患者均进行基础治疗共14 d,研究者则加用重组人生长激素4 iu每天一次皮下注射,共14 d,两组患者治疗前后分别作Mayo评分及检查血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)。结果研究组治疗前后Mayo评分改善(t值=15.425,P<0.001)、TNF–α下降(t值=7.080,P<0.001)差异均有显著性统计学意义,而IL-1β变化差异无显著性统计学意义(t值=0.402,P=0.691)。对照组治疗前后Mayo评分改善差异有显著性统计学意义(t值=9.165,P<0.001),TNF-α(t值=1.472,P=0.154)、IL-1β(t值=0.941,P=0.356)比较差异无显著性统计学意义。结论重组人生长激素可以有效降低溃疡性结肠炎患者血清TNF-α水平,促进溃疡性结肠炎患者大肠粘膜的修复。

Objective To study the effect of recombinant human growth hormone (r-hGH) in thetreatment of ulcerative colitis. Methods Fifty-five patients with ulcerative colitis were collected from 2011 to2016 in Second People′s Hospital of Huai′an, and were randomly grouped into research group (30 cases) and controlgroup (25 cases). Two groups of patients are comparable with age, occupation, duration, colonoscopy lesions scopeand Mayo score (t=0.163, P=0.163). Two groups of patients were under a total of 14 days treatment. The researchgroup was added with subcutaneous injection of recombinant human growth hormone, 4 iu qd, 14 days. Two groupsof patients were analyzed the Mayo score and serum tumor necrosis factor alpha (TNF alpha), interleukin 1 beta(IL-1 beta) before and after treatment respectively. Results In research group, the Mayo score (t=15.425,P < 0.001) and TNF alpha (t=7.080, P < 0.001) were of highly significant statistical difference before and aftertreatment, there was no significant statistical difference in IL-1 beta changes (t=0.402, P=0.402). In the controlgroup, the Mayo score was of significant statistical difference (t=9.165, P=9.165) before and after treatment,the TNF alpha beta (t=1.472, P=0.154), IL-1 (t=0.941, P=0.356) was of no significant statistical difference.Conclusion The recombinant human growth hormone can effectively reduce the blood level of TNF alpha inulcerative colitis patients, promoting restoration of large intestine mucosa in patients with ulcerative colitis.