降钙素、D-二聚体、C反应蛋白与重症社区获得性肺炎病情、预后判断的相关性研究

A study on the correlation among calcitonin, D-dimer and C-reactive protein and prognosis of severe community acquired pneumonia

目的:测定降钙素(PCT)、D-二聚体(D-dimer)、C反应蛋白(CRP)在重症社区获得性肺炎患者血清中的表达水平,探讨其与病情及预后的相关性。方法:选择我院2013年10月-2014年10月期间收治的65例重症社区获得性肺炎患者作为观察组,同期选择60例非重症社区获得性肺炎患者(肺炎对照组)及健康查体者(健康对照组)作对比研究,测定三组受试对象血清PCT、D-dimer、CRP水平,并进行统计学对比。结果:观察组患者的血清PCT、D-dimer、CRP水平均高于两个对照组,差异均存在统计学意义(P<0.05);两个对照组相比,肺炎对照组患者的PCT、D-dimer、CRP水平均高于健康对照组,差异亦都存在统计学意义(P<0.05)。结论:降钙素、D-二聚体、C反应蛋白在重症社区获得性肺炎患者血清中呈高表达,在一定范围内随着病情严重程度的增加,表达水平有增加趋势。因此,三者可作为重症社区获得性肺炎患者评估病情、判断预后以及检测治疗效果的指标。

Objective: To study the expression of calcitonin, D-dimer and C-reactive protein in sera of patients with severecommunity-acquired pneumonia, and to explore the correlation among them. Methods: 65 patients were selected as the observation group.60 non-severe community-acquired pneumonia patients (pneumonia control group) and healthy subjects (healthy control group) wereselected. The levels of serum PCT, D-dimer and CRP in 3 groups were measured and compared. Results: The serum levels of PCT, D-dimerand CRP in observation group were significantly highest than those in control groups (P<0.05). The levels of PCT, D-dimer and CRP incontrol group were significantly higher, CRP levels were higher than the healthy control group (P<0.05). Conclusion: The serum levelsof calcitonin, D-dimer and C-reactive protein are high in patients with severe community-acquired pneumonia, and the expression levelincreases with the severity of the disease in a certain range, can be used as severe community-acquired pneumonia patients to assess thedisease, determine the prognosis and detection of therapeutic effect of the check indicators.