小柴胡汤对肝癌肺转移的临床观察

Clinical observation on treating lung metastasis of liver carcinoma with the Xiaochaihu decoction

目的：评价小柴胡汤对肝癌肺转移的临床疗效。方法：选择我院收治的92例肝癌肺转移患者为研究对象，均分为对照组和治疗组。对照组应用伊立替康＋奥沙利铂＋5-FU/CF（FOLFIRINOX）方案进行化疗，治疗组在对照组的基础上口服小柴胡汤，14d为一个周期，2个周期后评价两组患者的疗效、血AFP含量以及血液学毒性反应。结果：治疗组的总有效率为71.74%，显著高于对照组的45.65%（P<0.05）；治疗组的血AFP下降发生41例，发生率为89.13%，显著高于对照组的65.22%（30例），差异具有统计学意义（P<0.05）；治疗后，治疗组3～4级白细胞下降发生率为19.57%，显著低于对照组的39.13%（P<0.05）。结论：在化疗的基础上给予小柴胡汤对肝癌肺转移进行治疗可增强疗效，降低毒副反应，值得临床推广。

Objective: To evaluate clinical efficacy of the Xiaochaihu decoction on lung metastasis of liver carcinoma. Methods:92 cases were evenly divided into the control group and treatment group. The control group was given irinotecan, oxaliplatin and chemotherapy. The treatment group took the Xiaochaihu decoction more, 14 cases as a course. Results: The total efficiency was 71.74% in the treatment group, better than 45.65% in the control group. In the treatment, the incidence of declining AFP was 89.13%, better than 45.65% in the control group (P<0.05). The declining of white blood cells in 3 to 4 levels was 19.57% in the treatment group, and lower than 39.13% in the control group (P<0.05). Conclusion: The Xiaochaihu decoction plus chemotherapy can enhance efficacy, reduce toxicity, and is worthy of clinical promotion.