中西医结合治疗乙肝后肝硬化腹水(气滞湿阻证)临床疗效分析

Clinical efficacy of the integrative medicine on ascites from posthepatitic cirrhosis

目的:观察鼓胀I方内服、水鼓散外敷联合西医常规疗法治疗肝硬化腹水(气滞湿阻证)的临床疗效。方法:将纳入鼓胀病临床路径管理的(气滞湿阻证)乙肝后肝硬化腹水患者60例随机均分为两组。对照组采用西医常规治疗方法,治疗组在对照组基础上采用鼓胀I方内服(疗程为8周)联合水鼓散外敷(疗程为2周)。治疗2周后评价综合疗效、主要症状(腹胀、纳差、胁痛)疗效,并于治疗结束后随访12个月,记录腹水复发情况。结果:在综合疗效方面,治疗组明显优于对照组(P<0.05)。治疗后两组患者的腹胀、纳差症状积分均降低(P<0.05),治疗组较对照组疗效更显著(P<0.05),且可改善胁痛症状积分(P<0.05)。随访1年中治疗组患者复发率显著低于对照组(P<0.05)。结论:在西医常规治疗的基础上,采用中医综合疗法能提高肝硬化腹水(气滞湿阻证)患者的综合疗效,减轻患者症状,减少腹水复发,值得进一步的应用和研究。

Objective: To observe clinical efficacy of the Guzhang I prescription, Shuigu San plus western medicine on ascites from posthepatitic cirrhosis. Results: 60 cases were randomly divided into two groups. The control group took conventional western medicine;the treatment group was given the Guzhang I prescription plus Shuigu San. Results: The total efficiency was better in the treatment group (P<0.05). Symptom score of bloating, anorexia were declined (P<0.05); while decline of those in the treatment group was more significant (P<0.05); and symptom scores of hypochondriac pain were improved (P<0.05). The recurrence rate in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion: TCM combined therapy plus western medicine can improve the comprehensive effect, alleviate symptoms and reduce relapse of ascites, and is worthy of further application.