急性脑梗死患者尿微量白蛋白,尿白蛋白/尿肌酐变化及意义

Changes and significance of urinary albumin and urinary albumin/ urinary creatinine in patients with acute cerebral infarction

目的:观察急性脑梗死患者尿微量白蛋白、尿白蛋白/尿肌酐变化,并探讨其临床意义。方法:回顾性分析我院2012年1月-2015年6月期间收治的130例急性脑梗死患者的临床资料(观察组),选择同期入院查体的100例健康体检者作为对照组,检测两组受试者24h尿微量白蛋白(m ALB)、尿白蛋白/尿肌酐、美国国立卫生研究院卒中量表(NIHSS)评分等指标,行统计学对比,并分析尿微量蛋白、尿白蛋白/尿肌酐与NIHSS评分的相关性。结果:观察组患者24h尿微量白蛋白为(318.9±107.9)mg,尿白蛋白/尿肌酐比值为(38.2±11.5),均明显高于对照组(P<0.05),尿微量白蛋白、尿白蛋白/尿肌酐比值与NIHSS评分呈显著正相关(r=0.45,r=0.31)。对照组受试对象尿微量白蛋白及尿白蛋白/尿肌酐比值与NIHSS评分无相关性(r=0.07)。结论:急性脑梗死患者尿微量白蛋白、尿白蛋白/尿肌酐较健康者明显增高,增高程度与脑梗死的严重程度存在一定相关性,可作为评估患者脑梗死程度、治疗效果的观察指标。

Objective: To observe changes of urinary albumin and urinary albumin / urinary creatinine in patients with acute cerebral infarction, and explore its clinical significance. Methods: Clinical data of 130 cases of acute cerebral infarction (the observation group) were retrospectiuely andlyzed; 100 cases of healthy subjects were selected as the control group. 24h urine albumin, urinary albumin / urinary creatinine, NIHSS score and other indicators were statistically compared; and the relationship between urine microprotein, urinary albumin/ creatinine and NIHSS score were analyzed. Results: The urinary microalbumin of (318.9±107.9) mg and urinary albumin / creatinine ratio of (38.2±11.5) in the observation group were significantly higher than those in the control group (P<0.05); urinary albumin, urinary albumin / creatinine ratio were positively correlated with NIHSS score (r =0.45, r =0.31). There was no correlation between urinary albumin and urinary albumin / creatinine ratio and NIHSS score (r =0.07) in the control subjects. Conclusion: Urinary albumin and urinary albumin / urinary creatinine in patients with acute cerebral infarction were significantly higher than those in healthy subjects. The degree of increase was related to the severity of cerebral infarction. It could be used as an index to evaluate the degree of cerebral infarction and the curative effect.