180例清热解毒类中药制剂的不良反应分析

An analysis of 180 cases of adverse reactions from the Qingre Jiedu medicine

目的：分析清热解毒类中药制剂不良反应的发生原因及特点，提出预防对策。方法：对我院2009年1月-2013年7月期间门诊及住院部发生清热解毒类中药制剂不良反应的180例患者进行回顾性分析，其中包括患者的性别、年龄、制剂类型、累及系统及其临床表现。结果：180例患者中，女性患者比例（60.02%）大于男性（39.98%）；0～13岁的儿童以及大于56岁的老年患者居多，分别占29.44%和48.56%；注射剂型不良反应占62.41%，高于其他剂型，且逐年上升；最常见累及系统是皮肤及黏膜。结论：医院应注意不良反应的及时反馈，在临床用药过程中加强不良反应的观察与监测，可有效减少并避免不良反应的发生，从而提高清热解毒类中药制剂的使用安全性。

Objective: To analyze the reason and characteristics of adverse reactions of the Qingre Jiedu medicine and put forward the preventive measures. Methods: The gender, age, type of preparation and clinical manifestations were retrospectively analyzed. Results:In 180 cases of adverse reaction, female was 60.02%, more than 39.98% of male. The proportions of children and elderly patients were 29.44% and 48.56% separately. The adverse reactions from injection accounted for 62.41% and were increased year by year, are higher than the others. The most common involved systems are skin and mucous membranes. Conclusion: In clinic, the adverse reaction should be timely fed back, observed and monitored. This information can effectively reduce and avoid adverse reactions, improve the safety of the Qingre Jiedu medicine.