乌司他丁对重症肺炎患者血清炎症因子影响研究

Study on the Effect of Ulinastatin on Serum Inflammatory Factors in Patients with Severe Pneumonia

目的:探究乌司他丁辅助治疗对重症肺炎患者血清炎症因子水平影响。方法:选取我院综合ICU病房收治的重症肺炎患者74例,随机分为对照组和治疗组,每组37例。对照组给予西医常规治疗,治疗组在其基础上加用乌司他丁。比较治疗前后两组患者IFN-γ,IL-6,TNF-α水平、血气分析氧合指数。结果:治疗后两组血气分析氧合指数水平升高(P<0.05),且治疗组血气分析氧合指数水平较高(P<0.05)。结论:乌司他丁可降低重症肺炎患者血清IFN-γ、IL-6、TNF-α水平,升高氧合指数,抑制炎性反应,对临床具有指导意义。

Objective: To explore the effects of ulinastatin adjuvant therapyon the level of serum in flammatory factors inpatients with severe pneumonia.Methods:74 cases patients with severe pneumonia from ICU ward of the department of internal medicine in our hospital were selected and divided into the control group and the experiment group by order of medical treatment and 37 cases in each group.The control group was treated by routine treatment of western medicine and the experiment group was treated on the base of the control group with ulinastatin.The IFN-γ,IL-6,TNF-α,oxygenation index of blood gas analysis and total clinical efficiency were compared before and after treatment.Results:The oxygenation index of blood gas analysis were increased(P<0.05),compared with the control group after treatment,the oxygenation index of blood gas analysis werehigher(P<0.05).Conclusion:Ulinastatin reduces the IFN-γ,IL-6,TNF-α level in patients with severe pneumonia,inhibiting the inflammatory reaction,has a great significance in clinical.