姜黄地上部分化学成分的研究

Chemical Constituents from Aerial Parts of Curcuma longa

为了解姜黄(Curcuma longa L.)地上部分的化学成分,采用硅胶、葡聚糖凝胶柱色谱和高效液相色谱从姜黄地上部分分离得到14个化合物。通过波谱分析,分别鉴定为槲皮素3-O-α-L-鼠李糖苷(1)、山柰酚3-O-α-L-鼠李糖(1→2)-α-L-鼠李糖苷(2)、橙皮素7-O-α-L-鼠李糖(1→6)-β-D-葡萄糖苷(3)、1,7-二(4-羟基苯基)庚烷-4E,6E-二烯-3-酮(4)、1,7-二(4-羟基苯基)庚烷-1E,4E,6E-三烯-3-酮(5)、3-羟基-4-甲氧基肉桂酸(6)、对羟基苯甲醛(7)、香草醛(8)、4-羟基-3-甲氧基苯甲酸(9)、异香草酸(10)、4-(1-羟基-1-甲基乙基)苯甲酸(11)、R-6-羟基-6-甲基-3-(2-羟基异丙基)-2-烯环己酮(12)、6,9-二羟基-4,7-巨豆二烯-3-酮(13)和β-胡萝卜苷(14)。化合物1、2、3、12和13首次从该植物中分离得到。经HPLC比较分析,姜黄地上部分缺乏姜黄药材的主要功能成分姜黄素。

In order to understand the chemical constituents of Curcuma longa L., fourteen compounds were isolated from its aerial parts. On the basis of spectral data, they were identified as quercetin 3-O-α-L-rhamnopyranoside(1), kaempferol 3-O-α-L-rhamnopyranosyl(1→2)-α-L-rhamnopyranoside (2), hesperetin 7-O-α-L-rhamnopyranosyl(1→6)-β-D-glucopy ranoside (3), 7-bis-(4-hydroxyphenyl)-4E,6E-heptadien-3-one (4), 1,7-bis-(4-hydroxyphenyl)-1E,4E,6E-heptadien-3-one (5), 3-hydroxy-4-methoxycinnamic acid (6), p-hydroxybenzaldehyde (7),vanillin (8), 4-hydroxy-3-methlbenzal acid (9), 3-hydroxy-4-methlbenzal acid (10), 4-(1-hydroxy-1-methylethyl)-benzoic acid (11), (R)-6-hydroxy-3-(2-hydroxypropan-2-yl)-6-methy-lcyclohex-2-enone (12), 6,9-dihydroxy-4,7-megastigmadien-3-one (13) and β-daucosterol (14). Compounds 1–3, 12 and 13 were isolated from this plant for the first time. Aerial parts of C. longa lacked curcumin derivatives, which are functional components common in the rhizomes.