维生素D与恶性肿瘤的关系

Relationship between vitamin D and cancer risk and prognosis

目的全球肿瘤发病率呈逐年升高趋势,其中膳食和生活方式与肿瘤发生、发展密切相关,本文对维生素D与各种常见恶性肿瘤发病和预后关系的相关研究进行系统回顾。方法检索已发表的相关文献,特别是Meta分析,对其结果进行汇总分析。结果体内维生素D水平与结直肠癌、乳腺癌、肺癌以及膀胱癌的发病风险呈负相关;维生素D干预还可改善血液系统恶性肿瘤患者预后;而维生素D与其他肿瘤的关系尚不明确。结论提高体内维生素D水平可能降低某些肿瘤的发病风险,并改善肿瘤患者预后。尚需国内外更多高质量的人群研究,以进一步阐明维生素D与肿瘤发生、发展的关系。

Objective The occurrence of cancer is increasing worldwide.It is known that diet and life style play important rolesin the incidence and progression of cancer.This review provided an overview of the association between vitamin D and cancer riskand prognosis.Methods The published literatures about vitamin D and cancer risk and prognosis,especially Meta analysis,wererecruited for further comprehensive summary.Results Vitamin D status was inversely associated with colorectal cancer,breastcancer,lung cancer and bladder cancer risk,and could improve the prognosis of hematological malignancies patients,however,theassociation between vitamin D and risk of other cancers is still inconclusive.Conclusions Adequate vitamin D status is associatedwith a lower risk of cancer,and can improve prognostic outcomes of cancer patients.More well-designed epidemiological studies areneeded for further investigation of the relationship between vitamin D and risk and prognosis of cancer.