石墨烯、石墨烯衍生物及其复合材料在组织工程中的应用进展

Application progress of graphene, graphene derivatives and graphene composites in tissue engineering

石墨烯是一种由碳原子以sp2杂化轨道组成的六角型平面多环芳香烃原子晶体。基于石墨烯的纳米材料具有卓越的理化性质,近年来在医疗应用领域的研究成为热点,可用在药物载体、基因传递、生物检测、肿瘤治疗、抗菌和组织工程等方面。该文综述了石墨烯材料的性能、制备方法和众多衍生物的特性,介绍了石墨烯类材料在组织工程方面的研究进展,包括在创伤愈合、干细胞工程、肌肉骨骼工程方向的应用,展望了石墨烯在组织工程领域未来的发展。

Graphene is one of the crystalline forms of carbon,which is composed of a single monolayer of sp2hybridized orbitals tightly packed to atwo-dimensional honeycomb lattice.Because of its remarkable physiochemical properties,graphene based nanomaterials have become a hot researchtopic in the field of biological applications,which are available in drug delivery,gene delivery,biological detection,tumor treatment,antibacterial,tissueengineering,etc.This paper reviews the material properties,preparation methods and many derivatives of graphene,and introduces the research progressof graphene based materials in tissue engineering,including the application in wound healing,stem cell engineering,skeletal muscle engineering.Thefuture development of graphene in the field of tissue engineering is prospected.