颈脊髓损伤后β-CTX与P1NP的检测及意义

Detection and significance of beta-CTX and P1NP after cervical spinal cord injury

目的:探讨颈脊髓损伤后β-CTX与P1NP的检测及意义。方法:收治颈脊髓损伤患者56例,所有患者均采取入院时及入院后2周、4周、8周、12周的静脉血,用电化学发光免疫分析仪检测血清P1NP和β-CTX水平。结果:入院后2周患者血清β-CTX值较入院时低,血清P1NP值较入院时高;入院后4周、8周、12周血清β-CTX值呈逐渐上升趋势,入院后4周、8周、12周血清P1NP值呈逐渐下降趋势。入院后12周血清β-CTX水平和入院时相比有明显升高,入院后12周血清P1NP水平和入院时相比有明显降低,差异均具有统计学意义(P<0.05)。结论:对颈脊髓损伤患者进行P1NP、β-CTX的检测,可以准确反映骨代谢情况。

Objective:To investigate the detection and significance of beta β-CTX and P1NP after cervical spinal cord injury.Methods:56 patients with cervical spinal cord injury were selected.All patients were extracted venous blood when admitted to hospital and 2 weeks,4 weeks,8 weeks,12 weeks of admission.They were used an electrochemical immunoassay to detect serum P1NP and β-CTX levels.Results:2 weeks after the admission of serum β-CTX value decreased compared with the admission time,the serum P1NP value increased compared with the admission time;4 weeks,8 weeks and 12 weeks serum β-CTX value increased gradually after admission,4 weeks,8 weeks,12 weeks serum P1NP value decreased gradually after admission.12 weeks after admission,the serum levels of β-CTX were significantly higher than those in admission.The serum P1NP levels were significantly decreased at 12 weeks after admission.The differences were statistically significant(P<0.05).Conclusion:Detection of P1NP and -CTX in patients with cervical spinal cord injury can accurately reflect the situation of bone metabolism.