噻托溴铵联合茶碱缓释片对COPD稳定期患者的临床疗效

Clinical curative effect of tiotropium bromide combined with theophylline sustained release tablets in the treatment of patients with COPD stabilization of group C

目的:探讨噻托溴铵联合茶碱缓释片对COPD稳定期患者的临床疗效。方法:收治COPD稳定期患者80例,随机分为两组。试验组给予噻托溴铵联合茶碱缓释片治疗,对照组给予信必可治疗,比较两组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、呼气峰值流速(PEF)、6 min步行实验(6MWT)、COPD急性发作的次数、应急药物的使用量、不良反应情况。结果:两组FEV1、PEF及6MWT的增加值、急性发作的次数及应急药物的使用量比较,差异均无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:噻托溴铵联合茶碱缓释片治疗COPD稳定期患者的临床疗效与信必可类似。

Objective:To explore the clinical curative effect of tiotropium bromide combined with theophylline sustained release tablets in the treatment of patients with COPD stabilization of group C.Methods:80 cases of patients with COPD stabilization group C were divided into two groups randomly.The experiment group was treated with tiotropium bromide combined with theophylline sustained release tablets,the control group was treated with symbicort,the forced expiratory volume in 1 second (FEV1),forced vitalcapacity (FVC),peak expiratory flow (PEF),6 min walk test (6 MWT),the number of acute outbreak of COPD,emergency drug useand adverse reactions in the two groups were compared.Results:There were no statistically significant difference of the addedvalue of FEV1,PEF and 6 MWT,the number of acute outbreak of COPD,emergency drug use between the two groups(P>0.05).There were no statistically significant difference of the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Tiotropium bromide combined with theophylline sustained release tablets in the treatment of patients with COPD stabilization of group C had the similar clinical curative effect as symbicort.