大网膜乳斑中肿瘤相关性巨噬细胞数量与胃癌的关系

Relationship between tumor associated macrophages and gastric cancer in the greater omentum milky spot

目的:探讨大网膜乳斑中肿瘤相关性巨噬细胞(TAMs)数量与胃癌的关系。方法:收治胃癌患者100例,选择同期良性胃部疾病患者100例为对照组,比较两组大网膜乳斑CD68^+/CD206^-、CD206^+巨噬细胞表达情况,探讨大网膜乳斑CD68^+/CD206^-、CD206^+巨噬细胞与T分期相关性。结果:不同组别大网膜乳斑CD68^+/CD206^-、CD206^+巨噬细胞表达情况比较,差异有统计学意义(P<0.05)。大网膜乳斑CD68^+/CD206^-、CD206^+巨噬细胞与T分期相关性分别为^-0.759(P<0.05),0.693(P<0.05)。结论:大网膜乳斑中TAMs CD206^+高表达及CD68^+/CD206^-低表达与肿瘤分期密切相关。

Objective:To explore the relationship between tumor associated macrophages(TAMs) and gastric cancer in the greater omentum milky spot.Methods:100 patients with gastric cancer were selected.100 patients with benign gastric disease were selected as the control group.We compared the expression of greater omentum milky spot CD68 +/CD206- and CD206 +macrophages of the two groups,and investigated the correlation between the greater omentum milky spot CD68 +/CD206- and CD206+ macrophages and the T stage.Results:In different groups,the expression of greater omentum milky spot CD68+/CD206- and CD206 + macrophages were different(P<0.05).The correlation between the greater omentum milky spot CD68 +/CD206- and CD206+ macrophages and the T stage was -0.759(P<0.05),0.693(P<0.05).Conclusion:The high expression of TAMs CD206+andlow expression of CD68+/CD206- in the greater omentum milky spot were closely related with tumor stage.