阿司匹林-g-壳聚糖衍生物的合成初探

Primary studies on synthesis of aspirin-g-chitosan derivatives

目的探讨阿司匹林-g-壳聚糖衍生物的合成方法。方法将一定量的阿司匹林和壳聚糖加入适量三氯甲烷中,在DCC和DMAP的催化下,于50℃下反应6 h,然后通过柱层析和薄层层析制备分离,得到产物。再运用薄层层析、红外光谱、紫外光谱等检测手段进行表征。结果经过薄层层析、红外光谱、紫外光谱等分析,所得到的产物为单一成分,并且可以确定为阿司匹林-g-壳聚糖酰胺衍生物。结论在一定的催化条件下,以阿司匹林和壳聚糖为原料,经过适当的分离纯化方法,可以初步得到阿司匹林-g-壳聚糖衍生物。

Objective To study the synthesis method of aspirin-g-chitosan derivatives. Methods Under the catalysis of DCC and DMAP, certain amount of aspirin and chitosan were added into the amount of chloroform, reactiing 6 h at 50℃ . The products were separated by column chromatography and preparative TLC. Then, TLC, IR, UV were used to characterize the product . Results After analysis of TLC, IR and UV, the obtained product is a single component, and it can be identified as aspirin-g-chitosan amide derivatives. Conclusion Under the condition of appropriate catalyst, taking aspirin and chitosan as raw materials, aspirin-g-chitosan derivatives can be synthesized preliminary by appropriate separation and purification methods.