血管紧张素原基因T174M多态性与子痫前期发病风险相关性的Meta分析

Correlation between polymorphism of angiotensinogen gene T174M and onset risk of preeclampsia:a Meta-analysis

目的探讨血管紧张素原(AGT)基因T174M多态性与子痫前期发病风险的相关性。方法计算机检索PubMed、EMbase、CBM、CNKI和WanFang数据库,查找关于AGT基因T174M多态性与子痫前期发病风险相关性的病例-对照研究,检索时限均为建库至2016年4月。由2位评价员按照纳入与排除标准独立进行文献筛选、提取资料和方法学质量评价后,采用Stata 12.0软件进行Meta分析。结果最终纳入6个病例-对照研究,共包括692例患者和1789例健康对照。Meta分析结果显示,AGT基因T174M多态性与子痫前期发病风险无相关性(M vs.T:OR=1.06,95%CI:0.73~1.53;MM vs.TT:OR=0.79,95%CI:0.33~1.94;TM vs.TT:OR=1.12,95%CI:0.74~1.71;MM+TM vs.TT:OR=1.09,95%CI:0.72~1.65;MM vs.TM+TT:OR=0.79,95%CI:0.32~1.92)。亚组分析及敏感性分析结果与总体分析结果相似。结论 AGT基因T174M多态性与子痫前期发病风险无相关性。鉴于纳入研究的数量限制,该结论尚需进一步验证。

Objective To investigate the correlation between polymorphism of angiotensinogen gene T174M(AGT gene T174M) and onset risk of preeclampsia. Methods The databases of PubMed, EMbase, CBM, CNKI and WanFang Database were retrieved with computer for searching the case-control studies on correlation between polymorphism of AGT gene T174M and onset risk of preeclampsia up to Apr. 2016. The literature was screened and data was extracted by 2 researchers independently according to inclusion and exclusion criteria, and after quality review on methodology the data was given a Meta-analysis by using Stata 12.0 software. Results There were totally 6 case-control studies included involving 692 patients and 1789 health controls. The results of Meta-analysis showed that there was no correlation between polymorphism of AGT gene T174M and onset risk of preeclampsia(M vs. T: OR=1.06, 95%CI: 0.73~1.53; MM vs. TT: OR=0.79, 95%CI: 0.33~1.94; TM vs. TT: OR=1.12, 95%CI:0.74~1.71; MM+TM vs. TT: OR=1.09, 95%CI: 0.72~1.65; MM vs. TM+TT: OR=0.79, 95%CI: 0.32~1.92). The results of sub-group analysis and sensitivity analysis were similar to those of total analysis. Conclusion There is no correlation between polymorphism of AGT gene T174M and onset risk of preeclampsia. As the quantitative limitation of included studies, the conclusion is needed further verification.