对比氧氟沙星与氯霉素治疗化脓性中耳炎的疗效

Comparison of the effect of levofloxacin and chloramphenicol in the treatment of suppurative otitis media

目的:对比氧氟沙星与氯霉素对化脓性中耳炎的疗效。方法:收治化脓性中耳炎患儿106例,平分为两组。接受氧氟沙星治疗的归入观察组,使用氯霉素治疗的归入对照组。治疗结束后,记录两组临床治疗总有效率,对比两组治疗过程中发生的不良反应情况。结果:治疗结束后,观察组治疗总有效率达94.34%,对照组为84.91%,两组比较差异有统计学意义(P<0.05)。同时,观察组发生不良反应4例,包括耳痛2例,瘙痒2例;对照组发生9例,包括血细胞减少2例,耳痛4例,瘙痒3例;两组不良反应发生率比较,差异有统计学意义(P<0.05)。结论:氧氟沙星治疗化脓性中耳炎的效果比氯霉素好,且不良反应较少,安全性更高。

Objective:To compare the effect of levofloxacin and chloramphenicol in the treatment of suppurative otitis media.Methods:106 children with suppurative otitis media were selected.They were randomly divided into the two groups on average.The observation group was treated with levofloxacin,while the control group was treated with chloramphenicol.After the end of treatment,the total effective rate of the two groups was recorded,and the adverse reactions occurred during the treatment of the twogroups were compared.Result:After the treatment,the total effective rate of treatment was 94.34% in the observation group and84.91% in the control group,and the difference between groups was statistically significant(P<0.05).At the same time,theobservation group had 4 cases of adverse reactions,including 2 cases of earache,2 cases of itching;the control group occurred in 9cases,including 2 cases of blood cell reduction,4 cases of earache,itching in 3 cases;the difference between groups was statistically significant(P<0.05).Conclusion:The effect of levofloxacin in the treatment of suppurative otitis media is better than that of chloramphenicol,and the adverse reaction is less,and the safety is higher.