逍遥散加减联合点阵激光治疗寻常性痤疮临床观察

Clinical Study on Treatment of Acne with Xiaoyao Powder Combined with Lattice Laser

目的:探讨逍遥散加减联合点阵激光治疗寻常性痤疮的临床可行性及有效性。方法:选取2015年7月-2016年5月笔者医院门诊收治的寻常性痤疮患者98例,采用双盲法将患者分为药物组和治疗组。药物组:49例,使用中药汤剂逍遥散治疗;治疗组:49例,在药物组基础上进行点阵激光治疗。对两组患者疗效进行评估,检测治疗前后患者肿瘤坏死因子(TNF-α)、白介素-8(IL-8)以及外周血中TLR2表达率、荧光强度改变情况。结果:治疗后,治疗组痤疮改善有效率为95.9%,明显高于药物组的85.7%,两组疗效比较,具有显著性差异(P<0.05)。治疗前,两组TNF-α、IL-8水平以及TLR2表达率、荧光强度比较差别无统计学意义(P>0.05);治疗后,治疗组较药物组TNF-α、IL-8水平、TLR2表达率、荧光强度改善效果好,差值具有统计学意义(P<0.05)。结论:逍遥散加减联合点阵激光治疗寻常性痤疮,患者症状改善明显,具有良好的治疗效果,值得临床推广应用。

Objective To investigate the clinical feasibility and effectiveness of Xiaoyao Powder Combined with dot matrix laser in the treatment of acne. Methods A total of 98 patients with acne were selected from our hospital during the period of 2015.7 to 2016.5. The patients were divided into two groups: the medication group and the treatment group. Each group hada total of 49 patients. The medicine group use traditional Chinese medicine decoction of Xiaoyao Powder, treatment group oflaser treatment in drug group based on the evaluation of the two groups of patients before and after treatment in patients withdiseases, detection of tumor necrosis factor (TNF-α) and interleukin -8 (IL-8) and TLR2 in the peripheral blood expression rate, fluorescence intensity. Results After treatment, the effective rate of treatment group was 95.9%, which was significantly higher than that of the drug group, and the treatment effect of the treatment group was significantly improved, the difference was statistically significant(P <0.05). Before treatment, two groups of TNF- alpha, IL-8 level and the expression rate of TLR2,the fluorescence intensity was no significant difference(P >0.05).After treatment, the treatment group compared with the drug group TNF- alpha, IL-8 level, the expression rate of TLR2 and improve the fluorescence intensity of the effect was good, with significant difference(P <0.05). Conclusion Xiaoyao Powder Combined with dot matrix laser treatment of acne, improve the symptoms of patients with good therapeutic effect, worthy of clinical application.