下肢深静脉血栓形成急性期及亚急性期炎症细胞和体温变化与中医证型相关性分析

Analysis on the Correlation between TCM Syndromes and Inflammatory Reaction and Body Temperature Changes of Acute and Subacute Deep Vein Thrombosis

目的探讨下肢深静脉血栓形成(DVT)急性期及亚急性期患者炎症细胞、体温变化与中医证型分布的相关性。方法采用横断面调查研究,纳入130例DVT急性期及亚急性期患者,采集年龄、性别、体温、血常规、下肢静脉彩超、中医四诊信息,进行中医辨证。分析炎症细胞与体温变化、中医证型的关系。结果湿热下注证、血瘀湿阻证、气滞络阻证分别为37、64、29例。中性粒细胞升高在血瘀湿阻证最为明显(P<0.05),与皮肤色红具有较密切的关联(OR=1.287,95%CI:9.412-21.247)。单核细胞升高在湿热下注证中最为明显,与腓肠肌压痛(OR=7.364,95%CI:1.189-45.603)、皮温升高(OR=6.683,95%CI:1.791-24.938)、皮肤紧绷(OR=6.107,95%CI:1.423-26.203)、乏力(OR=3.302,95%CI:1.002-9.169)等有较密切关联。体温升高在湿热下注证最为多见,以单核细胞升高最为多见。结论 DVT常伴炎症细胞及体温升高,湿热下注证与体温升高、单核细胞升高关系密切,血瘀湿阻证与中性粒细胞升高关系密切。

Objective To investigate the correlation between inflammatory cells,body temperature changes,andTCM syndromes of deep venous thrombosis(DVT)patients in acute and subacute phases.Methods The data of age,gender,body temperature,blood routine,venous ultrasonography,and four diagnostic information of130DVTpatients in acute and subcute phases were collected and analyzed in a cross-sectional study.The correlation betweeninflammatory cells and the changes of body temperature and TCM syndromes were analyzed.Results Among130DVT patients,37patients had damp-heat syndrome,64patients had blood stasis and dampness syndrome,and29patients had qi stagnation syndrome.Neutrophils increased most obviously in blood stasis and dampness syndrome(P<0.05),which had close correlation with the skin redness(OR=1.287,95%CI:9.412-21.247).The mononuclearcells increased most obviously in the damp-heat syndrome,which has close correlation with nouhof(OR=7.364,95%CI:1.189–45.603),high skin temperature(OR=6.683,95%CI:1.791–24.938),skin tightness(OR=6.107,95%CI:1.423–26.203)and weakness(OR=3.302,95%CI:1.002–9.169).The temperature rising was the most common in thedamp-heat syndrome,and the increase of mononuclear cells was the most common one.Conclusion DVT is oftenaccompanied with elevated levels of inflammatory cells and body temperature.Damp-heat syndrome has close correlation withbody temperature and mononuclear cells increasing.Dampness and blood stasis syndrome and neutrophils are closely related.