大黄消痔栓治疗湿热瘀阻型慢性非细菌性前列腺炎/慢性骨盆疼痛综合征临床研究

Clinical Study on Dahuang Xiaozhi Suppository in Treating Chronic Abacterial Prostatitis/Chronic Pelvic Pain Syndrome of Moist Heat and Blood Stasis Syndrome

目的观察大黄消痔栓治疗湿热瘀阻型慢性非细菌性前列腺炎/慢性骨盆疼痛综合征(CABP/CPPS)的临床疗效。方法选取CABP/CPPS湿热瘀阻型患者200例,随机分为观察组和对照组各100例。2组均停用抗感染药物和其他制剂,予饮食及生活干预。对照组予前列安栓,观察组予大黄消痔栓,每次1粒,每日1次,纳肛,置入肛门3~4 cm。10 d为1个疗程,疗程间隔2 d,治疗3个疗程。观察2组临床疗效及治疗前后NIH慢性前列腺炎症状指数(NIH-CPSI)评分、前列腺液白细胞计数、卵磷脂小体、尿流率变化。结果观察组总有效率为100%(100/100),对照组为78%(78/100),观察组明显高于对照组(P<0.05)。与治疗前比较,2组前列腺液白细胞计数、NIH-CPSI评分均降低(P<0.01),观察组明显低于对照组(P<0.01);治疗后2组卵磷脂小体++++者均增多(P<0.01),观察组明显多于对照组(P<0.01);2组尿流率均升高(P<0.05),观察组高于对照组(P<0.01)。结论大黄消痔栓治疗湿热瘀阻型CABP/CPPS疗效显著,效果优于前列安栓。

Objective To investigate the clinical efficacy of Dahuang Xiaozhi Suppository in treating chronicabacterial prostatitis/chronic pelvic pain syndrome(CABP/CPPS)of moist heat and blood stasis syndrome.Methods Two hundred patients of CABP/CPPS were randomly divided into control group and observation group,100cases in each group.2groups were disabled anti-infective meidicne and other preparations,and received diet and lifeintervention.The control group received the treatment of Qianliean Suppository,and the observation group receivedthe treatment of Dahuang Xiaozhi Suppository,one capsule each time,once a day,into the anus depth of about3–4cm.Ten days were a treatment course with two day interval between each course of treatment.The treatmentlasted for three courses.The clinical efficacy of the two groups was observed and compared.The indexes includingthe scores of NIH-CPSI,leukocyte count and lecithin corpuscles in prostatic fluid,and urinary flow rate wereevaluated.Results The total effective rate was100%(100/100)in the observation group and78%(78/100)in thecontrol group,and the observation group was much higher than control group(P<0.05).The scores of NIH-CPSI andleukocyte count in both groups were significantly lower after treatment(P<0.01),and those in observation group were significantly lower than those in control group(P<0.01).The cases with lecithin corpuscles++++in both groups weresignificantly more after treatment(P<0.01),and those in observation group were significantly more than those incontrol group(P<0.01).The peak flow rate and mean flow rate in both groups were higher after treatment(P<0.01),and it was higher in observation group(P<0.01).Conclusion The efficacy of Dahuang Xiaozhi Suppository intreating CABP/CPPS of moist heat and blood stasis syndrome is remarkable,and it is better than QianlieanSuppository.