摘要
目的探讨银杏酮酯滴丸对颈动脉粥样硬化斑块干预治疗的临床疗效及其机制。方法选取脑梗死并颈动脉粥样硬化患者92例,随机分成对照组和观察组,每组46例,对照组在常规治疗的基础上予以瑞伐他汀治疗;观察组在对照组的基础上再加用银杏酮酯滴丸治疗,治疗期均为6个月,测定每例患者治疗前后血脂、血糖、肝肾功能、肌酶、hs-CRP、MMP-9及颈动脉IMT、斑块大小、数量、面积等,采用SPSS11.0统计软件进行分析。结果观察组患者治疗后血中TC、TG、LDL-C及hs-CRP、MMP-9的水平均显著低于对照组同期,分别为(4.52±0.47)VS(5.29±0.51),(1.75±0.21)VS(2.01±0.22),(2.50±0.22)VS(2.90±0.27),(3.12±0.67)VS(4.21±0.72),(180.7±7.4)VS(281.2±9.1)(P<0.05),观察组患者治疗后IMT及斑块积分显著低于对照组同期(0.87±0.15)VS(1.14±0.19),(3.12±0.35)VS(4.62±0.42)(P<0.05)。结论银杏酮酯滴丸治疗颈动脉粥样斑块的临床疗效显著,安全性好。其作用机制可能与其抑制体内炎症因子有关。
Objective To observe the clinical effect and the mechanism of YinXing Guttate Dropping Pills in treatment of carotid artery atheromatous plaque. Methods Patients(92cases) with carotid artery atheromatous plaque were randomly divided into control and treatment groups,and each group had 30 cases. The patients in the control group were po administered with Rosuvastatin calcium Tablets, 1 tablet/time, once daily, on the basis treatment of carotid artery atheromatous. The patients in the treatment group were po administered with YinXing Guttate Dropping Pills, on the basis of the control group, 5 pills/time,three times daily. The patientsin the two groups took drugs six months. After treatment, the efficacy was evaluated, and the changes of TC,TG,LDL-C andhs-CRP,MMP-9 in two grops before and after treatment were compared. Results After treatment, the TC,TG,LDL-C and hs-CRP,MMP-9 of the patients in the treatment group were significantly decreased than that in the control group(4.52±0.47)VS(5.29±0.51),(1.75±0.21)VS(2.01±0.22), (2.50±0.22)VS(2.90±0.27), (3.12±0.67)VS(4.21±0.72), (180.7±7.4)VS(281.2±9.1)(P<0.05),The IMTand plaque scores were significantly decreased than that in the control group(0.87±0.15)VS(1.14±0.19),(3.12±0.35)VS(4.62±0.42)(P<0.05).Conclusion YinXing Guttate Dropping Pills has clinical curative effect in treatment of carotid artery atheromatous plaque. And the mechanisms of that may be the reduce of the hsCRP and MMP-9.
作者
陈焕清
符少萍
陈玉成
缪瑞明
Chen Huan-qing;Fu Shao-ping;Chen Yu-cheng;Miao Rui-ming(Department of Health Care,The second affiliated Hospital of Sun yat-sen University, Guangzhou,Guangdong,510120,China)
出处
《当代医学》
2017年第4期1-4,共4页
Contemporary Medicine
基金
广东省科技计划项目(2008B030301092)
关键词
银杏酮酯滴丸
动脉粥样硬化
斑块
瑞伐他汀
治疗
机制
YinXing Guttate Dropping Pills
Carotid artery atheromatous
Plaque
Rosuvastatin calcium
Treatment
Mechanism