乳杆菌噬菌体基因组学研究进展

Advances in Genomic Studies of Lactobacillus Phages

随着乳杆菌在乳品工业中的广泛应用,噬菌体污染对终产品造成的严重威胁日益增加。目前,噬菌体相关研究已从最初的形态学进入到了分子水平。许多噬菌体的全基因组测序工作已经完成。基因组研究有助于揭示噬菌体侵染宿主的机制,能挖掘其关键功能基因。本文基于乳杆菌噬菌体的基因组信息对主要乳杆菌噬菌体基因组的特征、功能基因组及比较基因组进行了分析和概述,为进一步研究噬菌体提供理论依据。

With the extensive application of Lactobacilli for the dairy industry, phage contamination has posed an increasingly serious threat to the final products. Currently, phage research has evolved from the morphological to the molecular level. The full-length genomic sequences of many phages have been acquired. Genomic studies have contributed to revealing the infective mechanisms of phages and in turn exploring the key functional genes. In this paper, the genomic characteristics, functional genomics and comparative genomics of the major Lactobacillus phages published were analyzed,aiming to provide a theoretical basis for further exploration of phages.