血清C反应蛋白、同型半胱氨酸生化指标检测在冠心病患者中的临床意义

Clinical significance of serum C-reactive protein and homocysteine biochemical index detection in coronary heart disease patients

目的研究分析血清C反应蛋白、同型半胱氨酸生化指标检测在冠心病患者中的临床意义。方法 194例冠心病患者,根据病情不同分为稳定型心绞痛组(66例)、不稳定型心绞痛组(66例)以及急性心肌梗死组(62例)。同时选取同期108例体检健康者作为对照组。比较四组研究对象的C反应蛋白、同型半胱氨酸生化指标。结果稳定型心绞痛组C反应蛋白为(12.81±4.72)mg/L,同型半胱氨酸为(15.63±3.72)μmol/L;不稳定型心绞痛组C反应蛋白为(13.23±4.22)mg/L,同型半胱氨酸为(14.22±4.19)μmol/L;急性心肌梗死组C反应蛋白为(17.22±2.12)mg/L,同型半胱氨酸为(19.23±4.22)μmol/L;对照组C反应蛋白为(2.60±0.33)mg/L,同型半胱氨酸为(9.02±3.23)μmol/L。稳定型心绞痛组、不稳定型心绞痛组以及急性心肌梗死组C反应蛋白、同型半胱氨酸水平均高于对照组,差异具有统计学意义(P<0.05)。急性心肌梗死组C反应蛋白、同型半胱氨酸水平高于稳定型心绞痛组、不稳定型心绞痛组,差异具有统计学意义(P<0.05)。结论血清C反应蛋白以及同型半胱氨酸生化指标可作为冠心病的主要检测指标,可以从根本上反映冠心病的实际情况。

Objective To research and analyze clinical significance of serum C-reactive protein and homocysteine biochemical index detection in coronary heart disease patients. Methods A total of 194 patients with coronary heart disease were divided by their different disease condition into stable angina pectoris group (66cases), unstable angina pectoris group (66 cases) and acute myocardial infarction group (62 cases). There were 108 healthy people at the same period as control group. Comparison was made on serum C-reactive protein and homocysteine biochemical index in the four groups. Results The stable angina pectoris group had C-reactiveprotein as (12.81±4.72) mg/L and homocysteine as (15.63±3.72) μmol/L. The unstable angina pectoris grouphad C-reactive protein as (13.23±4.22) mg/L and homocysteine as (14.22±4.19) μmol/L. The acute myocardial infarction group had C-reactive protein as (17.22±2.12) mg/L and homocysteine as (19.23±4.22) μmol/L.The control group had C-reactive protein as (2.60±0.33) mg/L and homocysteine as (9.02±3.23) μmol/L. Thestable angina pectoris group, unstable angina pectoris group and acute myocardial infarction group all had higherC-reactive protein and homocysteine levels than the control group, and their difference had statistical significance(P<0.05). The acute myocardial infarction group had higher C-reactive protein and homocysteine levels than the stable angina pectoris group and unstable angina pectoris group, and their difference had statistical significance (P<0.05).Conclusion As main detection indexes, serum C-reactive protein and homocysteine biochemical index can fundamentally reveal practical condition of coronary heart disease