白色念珠菌引起抗菌药物相关性腹泻的临床检验特点分析

Analysis of characteristics in clinical examination of Candida albicans-induced antibiotics-associated diarrhea

目的分析白色念珠菌引起抗菌药物相关性腹泻的临床检验特点。方法 80例抗菌药物相关性腹泻患者作为研究对象,对其实施细菌培养,按照细菌培养结果将全部患者分成非白色念珠菌感染组和白色念珠菌感染组,对两组患者的清蛋白、空腹血糖、血钾以及血钠水平进行观察比较。结果全部80例患者中共检出32例白色念珠菌。32例白色念珠菌感染组患者的清蛋白水平为(30.7±1.3)g/L,空腹血糖水平为(7.7±1.1)mmol/L,血钾水平为(4.3±0.2)mmol/L,血钠水平为(148.4±2.6)mmol/L;48例非白色念珠菌感染组患者的清蛋白水平为(34.6±1.1)g/L,空腹血糖水平为(5.6±0.9)mmol/L,血钾水平为(3.5±0.3)mmol/L,血钠水平为(142.4±2.3)mmol/L。白色念珠菌感染组患者空腹血糖、血钾以及血钠水平显著高于非白色念珠菌感染组,差异具有统计学意义(P<0.05);白色念珠菌感染组患者的清蛋白水平则显著低于非白色念珠菌感染组,差异具有统计学意义(P<0.05)。结论相较于非白色念珠菌感染,白色念珠菌感染患者的清蛋白、空腹血糖、血钾以及血钠水平明显不同,因此对白色念珠菌导致的抗菌药物相关性腹泻患者进行细菌培养,能为临床治疗方案的制定提供科学依据,让抗菌药物的应用合理性提高。

Objective To analyze characteristics in clinical examination of Candida albicans-induced antibiotics-associated diarrhea. Methods Bacterial culture was made in 80 patients with antibiotics-associated diarrhea as study subjects. The patients were divided by their bacterial culture outcomes into non Candida albicans group and Candida albicans group. Observation and comparison were made on albumin, fasting blood glucose, serum potassium and serum sodium levels between the two groups. Results Among the 80 patietns, there were 32 cases with detected Candida albicans. Candida albicans group with 32 cases had albumin as (30.7±1.3) g/L, fasting blood glucoseas (7.7±1.1) mmol/L, serum potassium as (4.3±0.2) mmol/L and serum sodium as (148.4±2.6) mmol/L. NonCandida albicans group with 48 cases had albumin as (34.6±1.1) g/L, fasting blood glucose as (5.6±0.9) mmol/L,serum potassium as (3.5±0.3) mmol/L and serum sodium as (142.4±2.3) mmol/L. Candida albicans group hadobviously higher fasting blood glucose, serum potassium and serum sodium levels than non Candida albicans group,and the difference had statistical significance (P<0.05). Candida albicans group had much lower albumin level than nonCandida albicans group, and their difference had statistical significance (P<0.05). Conclusion Comparing with nonCandida albicans infection, patients with Candida albicans infection had obviously different levels of albumin,fasting blood glucose, serum potassium and serum sodium. Therefore, bacterial culture in patients with Candida albicans-induced antibiotics-associated diarrhea can provide scientific reference in establishing clinical treatment scheme, and improve rationality in antibiotics application.