264例药源性血小板减少症分析

Analysis of 264 cases of drug-induced thrombocytopenia

目的:探讨各类药物导致药源性血小板减少症的规律和特点,为临床合理用药提供参考。方法:检索CNKI数据库中2005–2015年期间有关药物致血小板减少的文献资料,对其中符合纳入标准的175篇文献中报道的264例病例报告进行统计分析。结果:264例药源性血小板减少症患者中,男性患者多于女性患者,男女比例为1.4:1。青年患者(18–44岁)报告例数最多(28.03%)。抗感染药物所占比例最大(40.53%)。给药途径以静脉滴注为主(60.61%)。ADR发生时间多在用药2~7 d(41.48%)。大部分患者预后良好,其中痊愈、好转250例(94.7%)。结论:药源性血小板减少涉及药物种类较多,临床应提高对药源性血小板的认识,加强对高危人群及高危药物的预警防范。

Objective:To analyze the regular pattern and characteristics of drug-induced thrombocytopenia,and providereferences for the rational use of clinical drugs.Methods:The literature about drug-induced thrombocytopenia from2005to2015were collected from CNKI and264drug-induced thrombocytopenia cases involving in175articles were analyzed statistically.Results:The number of male patients were more than the number of female patients in the264cases,which ratio was1.4:1.Thecases of young patients(18–44years)were the most(28.03%).The anti-infective drugs accounted for the largest proportion(40.53%).Intravenous infusion was the primary administration route(60.61%).The occurrence time of ADR was mainly within2–7days(41.48%).Most cases had good prognosis,250cases cured or improved(94.7%).Conclusion:Various categories of drugs maycause drug-induced thrombocytopenia.Therefore,more attentions should be paid on the high-risk drugs and high-risk patients.