美罗培南致药物性肝损伤1例

One case of drug-induced liver injury caused by meropenem

1例85岁男性患者,诊断为重症肺炎合并I型呼吸衰竭。给予美罗培南(1.0 g,q 8 h,ivgtt)抗感染治疗,出现转氨酶急速升高,考虑为药物性肝损伤。临床药师对患者进行药学监护,详细排查患者正在使用的药物,探讨可能药物与不良反应的关联性,考虑为美罗培南导致的药物性肝损害,与临床医生积极沟通停用该药物,给予护肝治疗,并加强对患者肝功能的监护,最终患者好转出科。

One85-year-old male patient was suffered from severe pneumonia complicated with type I respiratory failure.After given meropenem(1.0g,q8h,ivgtt)anti-infective treatment,his transaminase rapidly rose,which was considered as druginducedliver injury.Clinical pharmacists took pharmaceutical care on the patient,investigated the used drugs for the patient in detail,and discussed the relationship between the possible drugs and adverse reactions.Clinical pharmacists considered the liver injury wasinduced by meropenem.Consequently,meropenem was stopped,and liver protection therapy was given.Besides,clinical pharmacistsalso strengthened the monitoring of liver function.Finally,the patient was discharged with a good health condition.