冻干重组人脑利钠肽治疗急诊急性心力衰竭的效果观察

Effect observation of lyophilized recombinant human brain natriuretic reptide in the treatment of emergency acute heart failure

目的:分析冻干重组人脑利钠肽治疗急诊急性心力衰竭的临床疗效。方法:收治急诊急性心力衰竭患者40例,随机分为A组和B组各20例,两组都给予标准的抗心力衰竭治疗,A组加用冻干重组人脑利钠肽治疗,观察两组治疗前与治疗48 h的治疗效果及心功能的变化。结果:治疗后,两组的心率、血浆N末端B型利钠肽原及左心室射血分数与治疗前比较均有明显改善,A组的改善程度要优于B组(P<0.05)。A组的有效率90%,B组的有效率80%。两组均无严重不良反应。结论:冻干重组人脑利钠肽治疗急诊急性心力衰竭具有显著的疗效,并且安全性高。

Objective:To analyze the clinical curative effect of lyophilized recombinant human brain natriuretic reptide in thetreatment of emergency acute heart failure.Methods:40patients with emergency acute heart failure were selected.They wererandomly divided into A group and B group with20cases in each.The two groups were given the standard anti heart failuretreatment.A group was plus given lyophilized recombinant human brain natriuretic reptide treatment.The treatment effects andheart function changes of two groups were observed before treatment and after48hours of treatment.Results:After treatment,theheart rate,plasma N terminal B type natriuretic peptide and left ventricular ejection fraction of two groups were significantlyimproved compared with those before treatment,and the improvement degree of A group was better than that of B group(P<0.05).The effective rate of A group was90%,and the effective rate of B group was80%.There were no serious adverse reactions in thetwo groups.Conclusion:Lyophilized recombinant human brain natriuretic reptide in the treatment of emergency acute heart failurehas a significant curative effect,and the safety is high.