普通肝素与低分子肝素应用于肺栓塞的安全性比较分析

Comparative analysis of the safety of unfractionated heparin and low molecular heparin in the treatment of pulmonary embolism

目的:研究普通肝素与低分子肝素治疗肺栓塞患者的疗效及安全性。方法:收治肺栓塞患者87例,随机分为甲组44例和乙组43例,甲组给予普通肝素治疗,乙组给予低分子肝素治疗,比较两组的治疗效果及并发症。结果:甲组的治疗有效率93.2%,乙组的治疗有效率90.7%,差异无统计学意义(P>0.05);乙组的不良反应发生率4.7%,明显低于甲组的22.7%(P<0.05)。结论:低分子肝素治疗肺栓塞患者具有较好的疗效,生物利用度高,不良反应较少,安全性较高,剂量效应稳定。

Objective:To study the curative effect and safety of unfractionated heparin and low molecular heparin in the treatmentof patients with pulmonary embolism.Methods:87patients with pulmonary embolism were selected.They were randomly dividedinto the first group with44cases and the second group with43cases.The first group was given unfractionated heparin treatment.The second group was given low molecular heparin treatment.The curative effects and complications of two groups were compared.Results:The effective rate of the first group was93.2%;the effective rate of the second group was90.7%;the difference was notstatistically significant(P>0.05).The adverse reaction rate of the second group was4.7%,which was significantly lower than22.7%of the first group(P<0.05).Conclusion:Low molecular heparin in the treatment of patients with pulmonary embolism has agood curative effect,high bioavailability,less adverse reactions,high safety,stable dose effect.