降钙素原联合C反应蛋白检测在儿童中枢神经系统感染诊断中的应用价值

Application value of procalcitonin and C reactive protein detection in the diagnosis of central nervous system infection in children

目的:探讨血清降钙素原及C反应蛋白联合检测在儿童中枢神经系统感染诊断中的应用价值。方法:收治中枢神经系统感染患儿50例以及健康儿童50例,分别定义为患儿组与健康组,使用免疫比浊法检测血清PCT及CRP水平。结果:患儿组PCT及CRP水平均表现为化脓性脑膜炎>细菌性脑膜炎>病毒性脑膜炎,且患儿组各类型患儿CRP水平显著高于健康组,细菌性脑膜炎和化脓性脑膜炎患儿PCT水平显著高于健康组;患儿组治疗7 d后,细菌性及化脓性脑膜炎患儿PCT、CRP均较治疗前显著降低,差异均有统计学意义(P<0.05)。结论:PCT联合CRP水平检测在中枢神经系统感染的诊断、严重程度鉴别以及治疗效果的评价中均有良好的应用价值。

Objective:To investigate the value of the serum procalcitonin and C reactive protein detection in the diagnosis ofcentral nervous system infection in children.Methods:50children with central nervous system infection and50healthy childrenwere selected.They were defined as the children group and the healthy group respectively.We detected the serum levels of PCTand CRP by the immune turbidimetry method.Results:The levels of PCT and CRP in children group were purulent meningitis>bacterial meningitis>viral meningitis,and the CRP level of various types of the children group were significantly higher than thatof the control group;the PCT level of the bacterial meningitis and purulent meningitis children were higher than the control group;after the treatment of7d,PCT and CRP in children with bacterial meningitis and purulent meningitis were significantly lower thanthose before the treatment;the differences were statistically significant(P<0.05).Conclusion:The detection of PCT and CRP hasgood application value in the diagnosis,differential diagnosis and therapeutic effect evaluation of central nervous system infection.