脑脊液乳酸和溶菌酶水平在诊断细菌性脑膜炎方面的应用价值

Application value of cerebrospinal fluid lactate and lysozyme levels in the diagnosis of bacterial meningitis

目的:探讨脑脊液乳酸和溶菌酶水平在诊断细菌性脑膜炎方面的应用价值。方法:收治细菌性脑膜炎患儿56例作为研究组A,病毒性脑膜炎患儿49例作为研究组B,健康体检儿50例作为对照组。结果:研究组A的脑脊液乳酸和溶菌酶水平均明显高于研究组B和对照组(P<0.05);治疗10 d后,研究组A的脑脊液乳酸和溶菌酶水平较治疗前明显下降(P<0.05)。结论:细菌性脑膜炎患儿的脑脊液乳酸和溶菌酶水平明显增高,因此检验患儿脑脊液乳酸和溶菌酶水平对细菌性脑膜炎患儿的早发现和早治疗具有重要意义。

Objective:To investigate the application value of cerebrospinal fluid lactate and lysozyme levels in the diagnosis ofbacterial meningitis.Methods:56bacterial meningitis children were as the research group A;49viral meningitis children were asthe study group B;50healthy children were as the control group.Results:The levels of lactic acid and lysozyme in cerebrospinalfluid of the study group A were significantly higher than those of the study group B and the control group(P<0.05);after10daystreatment,the levels of lactate and lysozyme in CSF of A group were significantly lower than those before the treatment(P<0.05).Conclusion:The levels of lactic acid and lysozyme in cerebrospinal fluid of children with bacterial meningitis were significantlyincreased,therefore,it is important for the early detection and early treatment to detect the level of lactic acid and lysozyme incerebrospinal fluid of children with bacterial meningitis.