老年男性代谢综合征患者血清CTRP1水平及其与血清脂联素水平的关系

Serum CTRP1 level and its relationship with serum adiponectin level in elderly male metabolic syndrome patients

目的·观察老年男性代谢综合征(MS)患者血清补体C1q肿瘤坏死因子相关蛋白1(CTRP1)水平的变化,并探讨其与血清脂联素(APN)水平的关系。方法·对279例60~90岁男性研究对象的临床资料进行回顾性分析,所有对象均经酶标记免疫吸附试验(ELISA)测定血清CTRP1和APN水平。其中MS患者105例(MS组),MS合并高血压患者(HMS组)90例,非MS患者(对照组)84例;记录一般资料,包括身高、体质量、收缩压、舒张压及空腹血糖、空腹胰岛素和血清三酰甘油(TAG),计算体质量指数(BMI)和稳态模型胰岛素抵抗指数(HOMA-IR)。结果·与对照组比较,MS组和HMS组患者血清CTRP1水平均升高,HMS组升高更明显;HMS组和MS组患者血清APN水平明显降低。血清CTRP1水平与APN水平呈负相关。血清CTRP1水平与血糖、BMI、收缩压、TAG和HOMA-IR呈正相关。结论·老年男性MS患者血清CTRP1水平升高,APN水平降低;MS合并高血压患者的血清CTRP1水平更高。血清CTRP1水平与多项动脉粥样硬化因素有关。

To observe the change of serum complement C1q tumor necrosis factor-related protein1 (CTRP1) level and explore its relationship with serum adiponectin (APN) level in elderly male metabolic syndrome (MS) patients. Methods · Clinical data of 279 male objects (60-90 years old) were analyzed retrospectively, serum CTRP1 and APN levels of all objects were tested by enzyme-linked immuno sorbent assay (ELISA).The patients were divided into three groups, i.e. 105 MS patients (MS group), 90 MS patients combined with hypertension (HMS group), and 84 non-MS patients (control group). All general information, including height, body weight, systolic blood pressure (SBP), diastolic blood pressure, fasting blood glucose, fasting insulin and serum three acyl glycerin (TAG) were recorded, in order to calculate body mass index (BMI) and homeostasis model assessment of insulin resistance (HOMA-IR). Results · Compared with the control group, serum CTRP1 levels of patients in MS group and HMSgroup both increased, and the latter was more obviously. Serum APN levels of patients decreased obviously in HMS group and MS group. The level ofserum CTRP1 was negatively related with the level of serum APN. Conversely, serum CTRP1 level was positively related with blood glucose, BMI,SBP, TAG and HOMA-IR. Conclusion · The level of serum CTRP1 is elevated, while the level of serum APN declines in elderly male MS patients.The serum level of CTRP1 is even higher in HMS patients. Serum CTRP1 level is related to many risk factors of atherosclerosis.