幽门螺杆菌外膜蛋白与黏附机制的研究进展

Research progress of mechanisms outer membrane proteins of Helicobacter pylori and its adherence

幽门螺杆菌是胃内一种长期慢性感染致病菌,其外膜蛋白(OMPs)包括脂蛋白、菌毛蛋白及一些黏附因子。这些黏附因子与幽门螺杆菌的黏附定植、持续感染和疾病的严重程度密切相关,而黏附是幽门螺杆菌定植及致病的关键。研究减弱黏附作用的疫苗已经成为当前的热点。该文就与黏附有关的OMPs、黏附受体、黏附机制及相关疫苗的研究进展作一综述。

Helicobacter pylori is a predominant pathogen inducing long-term chronic infection of stomach. Its outer membrane proteins (OMPs) mainly include lipoprotein, fimbriae protein and some adhesions. The adhesions are closely related to the pathogenic processes of adherence, colonization,persistent infection and severe clinical outcomes. In addition, the fact that adherence is vital for colonization and pathogenicity has made it a focus to study the vaccines against adherence. The OMPs related to adherence, their receptors, mechanisms of adherence, and the vaccines are summarized in this review.