坎地沙坦对阵发性房颤射频消融术后复发及房颤发作持续时间的影响

Influence of candesartan on recurrence and duration of atrial fibrillation attack after radiofrequency ablation for paroxysmal atrial fibrillation

目的探讨坎地沙坦对阵发性心房颤动(房颤)射频消融术后复发及房颤发作持续时间的影响。方法 64例阵发性房颤患者,均给予射频消融术治疗,术后随机分为治疗组和对照组,每组32例。治疗组口服坎地沙坦,对照组未给予药物。观察比较两组的复发次数及房颤持续时间。结果随访8~12个月,治疗组平均每例房颤复发次数(8.5±1.2)次少于对照组的(10.1±1.5)次,差异具有统计学意义(P<0.01)。治疗组平均房颤发作持续时间(10.5±2.3)min/次短于对照组的(41.3±3.6)min/次,差异具有统计学意义(P<0.01)。结论坎地沙坦可减少阵发性房颤射频消融术后的复发情况,且可缩短房颤发作持续时间。

Objective To explore influence of candesartan on recurrence and duration of atrial fibrillation attack after radiofrequency ablation for paroxysmal atrial fibrillation. Methods A total of 64 paroxysmal atrial fibrillation patients all treated with radiofrequency ablation were randomly divided into treatment group and control group, with 32 cases in each group. The treatment group received oral candesartan, and the control group received no medicine. Observation and comparison were made on recurrent frequency and duration of the atrial fibrillation attack in two groups. Results After follow-up review for 8~12 months, the treatment group had less average recurrence of atrial fibrillation as (8.5±1.2) times than (10.1±1.5) times in the control group, andtheir differences had statistical significance (P<0.01). The treatment group had shorter average duration of atrial fibrillation attack as (10.5±2.3) min/time than (41.3±3.6) min/time in the control group, and their difference had statistical significance (P<0.01). Conclusion Candesartan can reduce the recurrence after radiofrequency ablation for paroxysmal atrial fibrillation, and also can shorten the duration of atrial fibrillation attack.