艾司西酞普兰治疗焦虑症和抑郁症的临床疗效分析

Analysis of clinical effect by escitalopram in the treatment of anxiety and depression

目的研究在抑郁症与焦虑症中采取艾司西酞普兰治疗的临床效果。方法 62例焦虑症和抑郁症患者,依据疾病类型不同分为抑郁组与焦虑组,各31例。两组患者入院后均予以艾司西酞普兰治疗,对比分析两组患者焦虑、抑郁变化情况以及治疗效果。结果焦虑组总有效率为87.10%,抑郁组总有效率为90.32%,两组患者治疗总有效率比较差异无统计学意义(χ~2=0.1610,P>0.05)。焦虑组患者治疗前汉密尔顿抑郁评分(HAMD)评分为(26.35±3.15)分、汉密尔顿焦虑量表(HAMA)评分为(26.21±3.24)分,治疗后HAMD评分为(9.58±2.05)分、HAMA评分为(9.68±2.04)分,治疗后焦虑组患者HAMD、HAMA评分均低于治疗前,差异具有统计学意义(t=24.8439、24.0380,P<0.05)。抑郁组患者治疗前HAMD评分为(25.34±3.22)分、HAMA评分为(25.69±3.57)分,治疗后HAMD评分为(8.34±2.11)分、HAMA评分为(9.10±2.34)分,治疗后抑郁组患者HAMD、HAMA评分均低于治疗前,差异具有统计学意义(t=24.5866、21.6395,P<0.05)。结论在焦虑症和抑郁症临床治疗中艾司西酞普兰存在相对显著的效果,可以有效缓解患者焦虑、抑郁情绪,提升患者生存质量。

Objective To research clinical effect by escitalopram in the treatment of anxiety and depression. Methods A total of 62 patients with anxiety and depression were divided by different disease types into depression group and anxiety group, with 31 cases in each group. Both groups received escitalopram for treatment after admission. Comparison was made on changes of depression and anxiety status and curative effects between the two groups. Results The anxiety group had total effective rate as 87.10%, and the depression grouphad total effective rate as 90.32%. There was no statistically significant difference of total effective rate betweenthe two groups (χ2=0.1610, P>0.05). The anxiety group had Hamilton depression scale (HAMD) score beforetreatment as (26.35±3.15) points and Hamilton anxiety scale (HAMA) score as (26.21±3.24) points, and it hadHAMD score after treatment as (9.58±2.05) points and HAMA score as (9.68±2.04) points. After treatmentthe anxiety group had lower HAMD and HAMA scores than those before treatment, and the difference hadstatistical significance (t=24.8439, 24.0380, P<0.05). The depression group had HAMD score before treatmentas (25.34±3.22) points and HAMA score as (25.69±3.57) points, and it had HAMD score after treatment as(8.34±±2.11) points and HAMA score as (9.10±2.34) points. After treatment the depression group had lowerHAMD and HAMA scores than those before treatment, and the difference had statistical significance (t=24.5866,21.6395, P<0.05). Conclusion Escitalopram shows relatively excellent effect in clinical treatment of anxiety and depression. It can effectively relieve anxiety and depression emotion in patients, and improve their quality of life.