硝普钠与多巴胺和呋塞米合用治疗顽固性心衰疗效分析

Efficacy of Sodium Nitroprusside Combined with Dopamine and Furosemide in the Treatment of Refractory Heart Failure

目的:探讨硝普钠与多巴胺和呋塞米合用治疗顽固性心衰疗效。方法:选择2015年4月至2016年4月期间内新钢中心医院收治的顽固性心衰80例患者进行研究,采取抛骰子单双法将患者分为联合组(n=40)和常规组(n=40),给予常规组患者进行常规抗心衰治疗,给予联合组患者在常规组患者的基础上采取硝普钠与多巴胺和呋塞米合用治疗,统计对比两组患者的治疗效果。结果:联合组患者治疗后血浆利钠肽水平与常规组相比明显较低,P<0.05。联合组患者治疗后六分钟步行试验、左心室射血分数与常规组相比明显较高,P<0.05。联合组患者治疗总有效率与常规组相比明显较高,P<0.05。联合组患者治疗后复发率与常规组相比明显较低,P<0.05。结论:硝普钠与多巴胺和呋塞米合用治疗顽固性心衰效果显著,可在临床推广运用。

Objective: To study of sodium nitroprusside, dopamine and furosemide in combination in the treatment of refractory heart failure curative effect. Methods: 80 patients with refractory heart failure admitted to Xingang Central Hospital during April 2015 to April 2016 were divided into combined group (n=40) and normal group (n=40). Normal group was given routine group with conventional anti heart failure treatment, while the combination group was given sodium nitroprusside, dopamine and furosemide combination treatment, and the therapeutic effect was compared between the two groups of patients. Results: Plasma level of brain natriuretic peptide (BNP) in the combined group after treatment was significantly lower compared with the conventional group (P<0.05). The six minute walk test and left ventricular ejection fraction in the combined group were significantly higher compared with the conventional group (P<0.05). The total efficiency in the treatment group is significantly higher compared with the patients of conventional group (P<0.05). The recurrence rate in the combined group was significantly lower compared with the conventional group (P<0.05). Conclusion: Sodium nitroprusside, dopamine and furosemide combined treatment of intractable heart failure showed good effect, thus,should be widely used in clinical practice.