抗抑郁药联合α受体阻滞剂治疗慢性前列腺炎的临床观察

Clinical observation on antidepressive agents combined with α receptor blocker in the treatment of chronic prostatitis

目的探讨分析抗抑郁药联合α受体阻滞剂治疗慢性前列腺炎的临床疗效。方法 228例慢性前列腺炎患者,随机分为治疗组及对照组,各114例。治疗组应用抗抑郁药联合α受体阻滞剂治疗,对照组应用α受体阻滞剂联合维生素C治疗。治疗后,比较两组症状总有效率和抑郁总有效率,观察两组治疗前后的慢性前列腺炎症状评分表(NIH-CPSI)总体评分、抑郁自评量表(SDS)评分变化情况。结果治疗组症状总有效率91.23%高于对照组71.93%,差异具有统计学意义(χ2=14.126,P<0.05)。治疗组抑郁总有效率92.98%高于对照组76.32%,差异具有统计学意义(χ2=12.1848,P<0.05)。治疗前,两组患者的NIH-CPSI总体评分、SDS评分比较,差异均无统计学意义(P>0.05);治疗后,两组患者的NIH-CPSI总体评分、SDS评分均较治疗前明显下降,且治疗组下降程度优于对照组,差异均具有统计学意义(P<0.05)。结论抗抑郁药联合α受体阻滞剂治疗慢性前列腺炎的临床疗效显著,具有临床推广价值。

Objective To explore and analyze the clinical effect of antidepressive agents combined withαreceptor blocker in the treatment of chronic prostatitis.Methods A total of228chronic prostatitis patientswere randomly divided into treatment group and control group,with114cases in each group.The treatment groupreceived antidepressive agents combined withαreceptor blocker for treatment,and the control group receivedαreceptor blocker combined with vitamin C for treatment.Comparison were made on total symptoms effectiverate and total depression effective rate after treatment,and observation were made on National Institutes of Healthchronic prostatitis symptom index(NIH-CPSI)overall score,self-rating depression scale(SDS)score changes intwo groups before and after treatment.Results The treatment group had total symptoms effective rate as91.23%,which was higher than71.93%in the control group,and the difference had statistical significance(χ2=14.126,P<0.05).The treatment group had total depression effective rate as92.98%,which was higher than76.32%inthe control group,and the difference had statistical significance(χ2=12.1848,P<0.05).There was no statisticallysignificant difference in NIH-CPSI overall score and SDS score before treatment(P>0.05).After treatment,bothgroups had lower NIH-CPSI overall score and SDS score than before treatment,and the treatment group had lowerscores than the control group.Their differences had statistical significance(P<0.05).Conclusion Combinationof antidepressive agents andαreceptor blocker shows significant clinical effect in the treatment of chronicprostatitis,and this method has clinical popularization value.