探讨尼莫地平治疗蛛网膜下腔出血的临床效果

Investigation of clinical effect observation by nimodipine in the treatment of subarachnoid hemorrhage

目的研究分析蛛网膜下腔出血患者接受尼莫地平治疗的临床效果。方法 102例蛛网膜下腔出血患者,根据治疗方法不同分为对照组和研究组,各51例。对照组患者采用常规治疗,研究组患者在此基础上联合尼莫地平治疗,比较两组患者的治疗效果、预后、死亡、并发症发生情况。结果研究组患者治疗痊愈24例,好转20例,无效7例,总有效率为86.27%;对照组患者治疗痊愈20例,好转17例,无效14例,总有效率为72.55%,研究组患者治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。研究组格拉斯哥预后评分(GOS)5分患者为5.88%(3/51)、死亡率为7.84%(4/51)、并发症发生率为17.65%(9/51),均低于对照组的31.37%(16/51)、23.53%(12/51)、56.86%(29/51),差异具有统计学意义(P<0.05)。结论尼莫地平对蛛网膜下腔出血患者的临床治疗有效率较高,死亡率和并发症发生率有所下降,临床中可以延缓病情发展。

Objective To research clinical effect by nimodipine in the treatment of subarachnoidhemorrhage.Methods A total of102patients with subarachnoid hemorrhage were divided by differenttreatment measures into control group and research group,with51cases in each group.The control group receivedconventional therapy,and the research group received additional nimodipine to conventional therapy.Comparisonwas made on curative effect,prognosis,mortality and complications between the two groups.Results Theresearch group had24cured cases,20improved cases and7ineffective cases,along with total effective rate as86.27%.The control group had20cured cases,17improved cases and14ineffective cases,with total effective rates72.55%.The research group had higher total effective rate in treatment than the control group,and the differencehad statistical significance(P<0.05).The research group had proportion of5-point cases in Glasgow outcome score(GOS)as5.88%(3/51),mortality rate as7.84%(4/51)and incidence of complications as17.65%(9/51),whichwere all lower than31.37%(16/51),23.53%(12/51)and56.86%(29/51)in the control group,and their differencehad statistical significance(P<0.05).Conclusion Nimodipine shows high efficiency in clinical treatment forsubarachnoid hemorrhage patients,along with decreasing mortality rate and incidence of complications,and it cansuspend disease development in clinical treatment.