甲硝唑与奥硝唑治疗宫颈糜烂的疗效及对免疫球蛋白、炎性细胞因子的影响分析

Analysis of the curative effect of metronidazole and ornidazole in the treatment of cervical erosion and the influence of immunoglobulin and inflammatory cytokines

目的:探讨甲硝唑与奥硝唑治疗宫颈糜烂的疗效及对免疫球蛋白、炎性细胞因子的影响。方法:收治宫颈糜烂患者160例,随机分成A、B两组,各80例。两组均给予微波治疗,A组在此基础上给予奥硝唑,B组给予甲硝唑,比较两组的疗效,检测治疗前后免疫球蛋白和炎性细胞因子水平。结果:A组总有效率为96.3%,B组为87.5%,差异具有统计学意义(P<0.05)。治疗后两组炎性细胞因子明显减少,A组炎性细胞因子更少。结论:甲硝唑和奥硝唑均可降低炎性细胞因子水平,相较于甲硝唑,奥硝唑在宫颈糜烂中的疗效更佳。

Objective:To explore the curative effect of metronidazole and ornidazole in the treatment of cervical erosion and the influence of immunoglobulin and inflammatory cytokines.Methods:160patients with cervical erosion were selected.They were randomly divided into two groups,and the two groups were treated with microwave treatment.The A group was given ornidazole on this basis,and the B group was given metronidazole.The curative effects of two groups were compared.The immunoglobulin and inflammatory cytokines levels were detected before and after treatment.Results:The total effective rate of the A group was96.3%,the total effective rate of the B group was87.5%,and the difference was statistically significant(P<0.05).After treatment,the inflammatory cytokines in the two groups were significantly decreased,and the inflammatory cytokines of the A group were lower.Conclusion:Metronidazole and ornidazole can reduce the level of inflammatory cytokines.Compared with metronidazole,the curative effect of ornidazole is better in the treatment of cervical erosion.